Standard Name	EDC3 1
Systematic Name	YEL015W
Alias	DCP3 , LSM16
Feature Type	ORF, Verified
Description	Non-essential conserved protein with a role in mRNA decapping; specifically affects the function of the decapping enzyme Dcp1p; localizes to cytoplasmic mRNA processing bodies; forms cytoplasmic foci upon DNA replication stress (2, 3)
Name Description	Enhancer of mRNA DeCapping 1, 2

Chromosomal Location	ChrV:126629 to 128284 | ORF Map | GBrowse

	View Computational GO annotations for EDC3
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	cytoplasmic mRNA processing body assembly (IGI, IMP) deadenylation-independent decapping of nuclear-transcribed mRNA (IMP)
Cellular Component
Manually curated	cytoplasmic mRNA processing body (IDA)
High-throughput	cytoplasm (IDA)

Classical genetics
null	Lsm1p-GFP distribution: abnormal viable
Large-scale survey
null	competitive fitness: decreased haploinsufficient vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	117 total interaction(s) for 65 unique genes/features.
Physical Interactions	Affinity Capture-MS: 34 Affinity Capture-RNA: 1 Affinity Capture-Western: 2 Biochemical Activity: 3 Co-localization: 1 PCA: 3 Protein-peptide: 1 Reconstituted Complex: 4 Two-hybrid: 34
Genetic Interactions	Negative Genetic: 13 Phenotypic Enhancement: 1 Phenotypic Suppression: 1 Positive Genetic: 2 Synthetic Growth Defect: 14 Synthetic Lethality: 2 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrV:126629 to 128284 | ORF Map | GBrowse
Last Update	Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1656 126629..128284 1996-07-31 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000741