CDC39/YCR093W Summary Help

Standard Name CDC39 1, 2
Systematic Name YCR093W
Alias NOT1 3 , ROS1 , SMD6
Feature Type ORF, Verified
Description Component of the CCR4-NOT1 core complex; this complex has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor (4, 5)
Name Description Cell Division Cycle 6
Chromosomal Location
ChrIII:280117 to 286443 | ORF Map | GBrowse
Genetic position: 91 cM
Gene Ontology Annotations All CDC39 GO evidence and references
  View Computational GO annotations for CDC39
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 8 genes
Classical genetics
reduction of function
Large-scale survey
reduction of function
215 total interaction(s) for 81 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 79
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 42
  • Co-crystal Structure: 1
  • Co-fractionation: 1
  • Co-purification: 11
  • PCA: 21
  • Reconstituted Complex: 3
  • Two-hybrid: 19

Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 8
  • Phenotypic Suppression: 3
  • Positive Genetic: 1
  • Synthetic Haploinsufficiency: 1
  • Synthetic Lethality: 10
  • Synthetic Rescue: 11

Expression Summary
Length (a.a.) 2,108
Molecular Weight (Da) 240,277
Isoelectric Point (pI) 6.4
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrIII:280117 to 286443 | ORF Map | GBrowse
This feature contains embedded feature(s): YCRX20C
Genetic position: 91 cM
Last Update Coordinates: 2011-02-03 | Sequence: 2000-09-13
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..6327 280117..286443 2011-02-03 2000-09-13
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000689
References cited on this page View Complete Literature Guide for CDC39
1) Reed SI  (1980) The selection of S. cerevisiae mutants defective in the start event of cell division. Genetics 95(3):561-77
2) Breter HJ, et al.  (1983) Isolation and transcriptional characterization of three genes which function at start, the controlling event of the Saccharomyces cerevisiae cell division cycle: CDC36, CDC37, and CDC39. Mol Cell Biol 3(5):881-91
3) Collart MA and Struhl K  (1994) NOT1(CDC39), NOT2(CDC36), NOT3, and NOT4 encode a global-negative regulator of transcription that differentially affects TATA-element utilization. Genes Dev 8(5):525-37
4) Liu HY, et al.  (2001) Characterization of CAF4 and CAF16 reveals a functional connection between the CCR4-NOT complex and a subset of SRB proteins of the RNA polymerase II holoenzyme. J Biol Chem 276(10):7541-8
5) Russell P, et al.  (2002) Characterization of mutations in NOT2 indicates that it plays an important role in maintaining the integrity of the CCR4-NOT complex. J Mol Biol 322(1):27-39
6) Hartwell LH, et al.  (1970) Genetic control of the cell-division cycle in yeast. I. Detection of mutants. Proc Natl Acad Sci U S A 66(2):352-9