KIN82/YCR091W Summary Help

Standard Name KIN82 1
Systematic Name YCR091W
Alias FPK2 2
Feature Type ORF, Verified
Description Putative serine/threonine protein kinase; implicated in the regulation of phospholipid asymmetry through the activation of phospholipid translocases (flippases) Lem3p-Dnf1p/Dnf2p; KIN82 has a paralog, FPK1, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description protein KINase 1
Chromosomal Location
ChrIII:274404 to 276566 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All KIN82 GO evidence and references
  View Computational GO annotations for KIN82
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
High-throughput
Cellular Component
Manually curated
Regulators 2 genes
Resources
Classical genetics
overexpression
Large-scale survey
null
overexpression
unspecified
Resources
160 total interaction(s) for 101 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • Affinity Capture-RNA: 2
  • Biochemical Activity: 28
  • Reconstituted Complex: 3

Genetic Interactions
  • Dosage Growth Defect: 6
  • Negative Genetic: 114
  • Positive Genetic: 1
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 720
Molecular Weight (Da) 81,462
Isoelectric Point (pI) 8.72
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIII:274404 to 276566 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2163 274404..276566 2011-02-03 2011-02-03
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000687
References cited on this page View Complete Literature Guide for KIN82
1) Wilson C, et al.  (1992) A putative serine/threonine protein kinase gene on chromosome III of Saccharomyces cerevisiae. Yeast 8(1):71-7
2) Nakano K, et al.  (2008) Protein kinases Fpk1p and Fpk2p are novel regulators of phospholipid asymmetry. Mol Biol Cell 19(4):1783-97
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4) Roelants FM, et al.  (2010) A protein kinase network regulates the function of aminophospholipid flippases. Proc Natl Acad Sci U S A 107(1):34-9