ABP1/YCR088W Summary

ABP1 BASIC INFORMATION

Standard Name	ABP1 1, 2
Systematic Name	YCR088W
Feature Type	ORF, Verified
Description	Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization (1, 3, 4)
Name Description	Actin Binding Protein 2

GO Annotations	All ABP1 GO evidence and references
	View Computational GO annotations for ABP1
Molecular Function
Manually curated	actin filament binding (IDA)
Biological Process
Manually curated	actin cortical patch assembly (IMP) establishment of cell polarity (IMP) protein localization (IMP)
Cellular Component
Manually curated	actin cortical patch (IDA) cell cortex (IDA)
High-throughput	cytoplasm (IDA) mating projection tip (IDA)

Mutant Phenotype	All ABP1 Phenotype details and references
Classical genetics
null	actin cytoskeleton morphology: abnormal Srv2p distribution: abnormal Inp52p-delta37C-GFP distribution: abnormal resistance to sodium chloride: decreased sporulation efficiency: decreased
overexpression	actin cytoskeleton morphology: abnormal bipolar budding pattern: increased cell size: increased inviable
unspecified	Prk1p distribution: abnormal Ark1p distribution: abnormal
Large-scale survey
null	replicative lifespan: increased viable
overexpression	inviable

Interactions	ABP1 All interactions details and references
	101 total interaction(s) for 45 unique genes/features.
Physical Interactions	Affinity Capture-MS: 18 Affinity Capture-RNA: 1 Affinity Capture-Western: 11 Co-fractionation: 3 Co-localization: 4 FRET: 2 Protein-peptide: 13 Reconstituted Complex: 2 Two-hybrid: 28
Genetic Interactions	Phenotypic Enhancement: 2 Synthetic Growth Defect: 4 Synthetic Haploinsufficiency: 1 Synthetic Lethality: 10 Synthetic Rescue: 2

Sequence Information

ChrIII:265065 to 266843 | |

Genetic position: 80 cM

Last Update

Coordinates: 2006-01-12 | Sequence: 1997-01-28

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1779	265065..266843	2006-01-12	1997-01-28

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000000684

ABP1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for ABP1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for ABP1]

1)	Drubin DG, et al. (1990) Homology of a yeast actin-binding protein to signal transduction proteins and myosin-I. Nature 343(6255):288-90
2)	Drubin DG, et al. (1988) Yeast actin-binding proteins: evidence for a role in morphogenesis. J Cell Biol 107(6 Pt 2):2551-61
3)	Mulholland J, et al. (1994) Ultrastructure of the yeast actin cytoskeleton and its association with the plasma membrane. J Cell Biol 125(2):381-91
4)	Olazabal IM and Machesky LM (2001) Abp1p and cortactin, new "hand-holds" for actin. J Cell Biol 154(4):679-82

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