PAT1/YCR077C Summary Help

PAT1 BASIC INFORMATION

Standard Name PAT1
Systematic Name YCR077C
Alias MRT1
Feature Type ORF, Verified
Description Topoisomerase II-associated deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; functionally linked to Pab1p (1, 2, 3, 4)
Name Description Protein Associated with Topoisomerase II 3
GO Annotations All PAT1 GO evidence and references
    View Computational GO annotations for PAT1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All PAT1 Phenotype details and references
Classical genetics
null
Large-scale survey
null
overexpression
Interactions PAT1 All interactions details and references
422 total interaction(s) for 285 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 65
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 15
  • Co-purification: 3
  • PCA: 6
  • Protein-RNA: 3
  • Two-hybrid: 39
Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Lethality: 1
  • Dosage Rescue: 3
  • Phenotypic Enhancement: 171
  • Phenotypic Suppression: 53
  • Synthetic Growth Defect: 33
  • Synthetic Lethality: 25
  • Synthetic Rescue: 3
Sequence Information
ChrIII:252625 to 250235 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
This feature contains embedded feature(s): YCRX15W
Gbrowse
Last Update Coordinates: 2006-01-12 | Sequence: 2000-09-13
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2391 252625..250235 2006-01-12 2000-09-13
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000000673

PAT1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for PAT1

NOMENCLATURE CONFLICT NOTE

NameRelevanceDescription
PXA2Nomenclature conflictPAT1 has been used in the literature to refer to both PAT1/YCR077C, which is involved in translational initiation and chromosome segregation, and PXA2/YKL188C, which encodes a ABC transporter-2.
GNA1Nomenclature conflictPAT1 has been used in the literature to refer to both PAT1/YCR077C, which is involved in translational initiation and chromosome segregation and GNA1/YFL017C, which encodes a glucosamine-phosphate N-acetyltransferase.

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for PAT1]

1) Wang X, et al.  (1999) The topoisomerase II-associated protein, Pat1p, is required for maintenance of rDNA locus stability in Saccharomyces cerevisiae. Mol Gen Genet 261(4-5):831-40
2) Bonnerot C, et al.  (2000) The two proteins Pat1p (Mrt1p) and Spb8p interact in vivo, are required for mRNA decay, and are functionally linked to Pab1p. Mol Cell Biol 20(16):5939-46
3) Wang X, et al.  (1996) Pat1: a topoisomerase II-associated protein required for faithful chromosome transmission in Saccharomyces cerevisiae. Nucleic Acids Res 24(23):4791-7
4) Noueiry AO, et al.  (2003) Yeast Lsm1p-7p/Pat1p deadenylation-dependent mRNA-decapping factors are required for brome mosaic virus genomic RNA translation. Mol Cell Biol 23(12):4094-106