Standard Name	SSK22
Systematic Name	YCR073C
Feature Type	ORF, Verified
Description	MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway; functionally redundant with Ssk2p; interacts with and is activated by Ssk1p; phosphorylates Pbs2p; SSK22 has a paralog, SSK2, that arose from the whole genome duplication (1, 2, 3)
Name Description	Suppressor of Sensor Kinase

Chromosomal Location	ChrIII:246583 to 242588 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for SSK22
Molecular Function
Manually curated	MAP kinase kinase kinase activity (ISS)
High-throughput	protein kinase activity (IDA)
Biological Process
Manually curated	MAPK cascade involved in osmosensory signaling pathway (IMP, ISS)
High-throughput	protein phosphorylation (IDA)
Cellular Component
Manually curated	cellular_component unknown (ND)

Regulatory modules	predicted: cellcycle (323)

Classical genetics
null	resistance to tunicamycin: normal resistance to L-1,4-dithiothreitol: decreased resistance to mercaptoethanol: decreased
Large-scale survey
null	competitive fitness: increased viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	64 total interaction(s) for 55 unique genes/features.
Physical Interactions	Affinity Capture-MS: 9 Affinity Capture-RNA: 3 Affinity Capture-Western: 1 Biochemical Activity: 17 Two-hybrid: 6
Genetic Interactions	Dosage Rescue: 5 Negative Genetic: 6 Phenotypic Enhancement: 2 Phenotypic Suppression: 1 Positive Genetic: 3 Synthetic Growth Defect: 5 Synthetic Haploinsufficiency: 2 Synthetic Lethality: 3 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIII:246583 to 242588 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	This feature contains embedded feature(s): YCRX12W
Last Update	Coordinates: 2011-02-03 | Sequence: 2000-09-13
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..3996 246583..242588 2011-02-03 2000-09-13
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000669