Standard Name	THR4 1
Systematic Name	YCR053W
Feature Type	ORF, Verified
Description	Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway (2, 3)
Name Description	THReonine requiring

Chromosomal Location	ChrIII:216697 to 218241 | ORF Map | GBrowse
	Genetic position: 51 cM

	View Computational GO annotations for THR4
Molecular Function
Manually curated	threonine synthase activity (IMP)
Biological Process
Manually curated	threonine biosynthetic process (IMP)
Cellular Component
High-throughput	cytoplasm (IDA) nucleus (IDA)

Pathways	superpathway of threonine and methionine biosynthesis superpathway of threonine biosynthesis threonine biosynthesis

Classical genetics
null	UV resistance: decreased alkaline pH resistance: decreased auxotrophy tellurium atom accumulation: decreased cold sensitivity: increased endocytosis: decreased heat sensitivity: increased ionic stress resistance: decreased resistance to tellurite: increased resistance to homoserine: decreased
unspecified	auxotrophy
Large-scale survey
null	acid pH resistance: decreased competitive fitness: decreased hyperosmotic stress resistance: decreased ionic stress resistance: decreased petite-negative resistance to tacrolimus (anhydrous) and tunicamycin: increased resistance to 1,4-dithiothreitol and tacrolimus (anhydrous): increased resistance to citric acid: decreased resistance to 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid: decreased resistance to hydroxyurea: decreased resistance to sirolimus: decreased resistance to (S)-lactic acid: decreased resistance to hydrogen chloride: decreased resistance to boric acid: decreased resistance to sodium selenide: decreased resistance to doxorubicin: decreased resistance to sorbate: decreased respiratory growth: decreased rate sporulation: decreased sporulation efficiency: decreased toxin resistance: decreased utilization of nitrogen source: absent vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	446 total interaction(s) for 339 unique genes/features.
Physical Interactions	Affinity Capture-MS: 11 Affinity Capture-RNA: 2 Protein-peptide: 1
Genetic Interactions	Negative Genetic: 371 Positive Genetic: 45 Synthetic Growth Defect: 4 Synthetic Lethality: 10 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIII:216697 to 218241 | ORF Map | GBrowse
	Genetic position: 51 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1545 216697..218241 2011-02-03 1997-01-28
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000649