RSC6/YCR052W Summary Help

Standard Name RSC6 1
Systematic Name YCR052W
Feature Type ORF, Verified
Description Component of the RSC chromatin remodeling complex; essential for mitotic growth; RSC6 has a paralog, SNF12, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description Remodel the Structure of Chromatin 1
Chromosomal Location
ChrIII:214994 to 216445 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All RSC6 GO evidence and references
  View Computational GO annotations for RSC6
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 5 genes
Resources
Classical genetics
null
repressible
Large-scale survey
conditional
null
reduction of function
repressible
Resources
215 total interaction(s) for 123 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 97
  • Affinity Capture-Western: 11
  • Biochemical Activity: 2
  • Co-purification: 2
  • PCA: 2
  • Reconstituted Complex: 8
  • Two-hybrid: 4

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 44
  • Phenotypic Suppression: 1
  • Positive Genetic: 40
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 483
Molecular Weight (Da) 54,165
Isoelectric Point (pI) 4.53
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIII:214994 to 216445 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1452 214994..216445 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000648
References cited on this page View Complete Literature Guide for RSC6
1) Cairns BR, et al.  (1996) RSC, an essential, abundant chromatin-remodeling complex. Cell 87(7):1249-60
2) Lorch Y, et al.  (1998) Activated RSC-nucleosome complex and persistently altered form of the nucleosome. Cell 94(1):29-34
3) Neely KE and Workman JL  (2002) The complexity of chromatin remodeling and its links to cancer. Biochim Biophys Acta 1603(1):19-29
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61