Standard Name	RSC6 1
Systematic Name	YCR052W
Feature Type	ORF, Verified
Description	Component of the RSC chromatin remodeling complex; essential for mitotic growth; RSC6 has a paralog, SNF12, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description	Remodel the Structure of Chromatin 1

Chromosomal Location	ChrIII:214994 to 216445 | ORF Map | GBrowse

	View Computational GO annotations for RSC6
Molecular Function
Manually curated	contributes_to DNA translocase activity (IDA)
Biological Process
Manually curated	ATP-dependent chromatin remodeling (IDA) G1 phase of mitotic cell cycle (IGI) G2/M transition of mitotic cell cycle (IMP) nucleosome disassembly (IDA) nucleosome positioning (IDA) positive regulation of transcription elongation from RNA polymerase II promoter (IDA)
Cellular Component
Manually curated	RSC complex (IDA)

Classical genetics
null	inviable
repressible	cell cycle progression through the G2/M phase transition: arrested Pmp2GFP-KKTN distribution: decreased
Large-scale survey
conditional	heat sensitivity: increased
null	cell size: increased competitive fitness: decreased haploinsufficient heat sensitivity: increased inviable resistance to sulfanilamide: decreased toxin resistance: decreased
reduction of function	competitive fitness: increased
repressible	chromosome/plasmid maintenance: decreased Pmp2GFP-LRKR distribution: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	214 total interaction(s) for 123 unique genes/features.
Physical Interactions	Affinity Capture-MS: 96 Affinity Capture-Western: 11 Biochemical Activity: 2 Co-purification: 2 PCA: 2 Reconstituted Complex: 8 Two-hybrid: 4
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 44 Phenotypic Suppression: 1 Positive Genetic: 40 Synthetic Growth Defect: 1 Synthetic Lethality: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIII:214994 to 216445 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1452 214994..216445 2011-02-03 1997-01-28
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000648