RSC6/YCR052W Summary

RSC6 BASIC INFORMATION

Standard Name	RSC6
Systematic Name	YCR052W
Feature Type	ORF, Verified
Description	Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p (1, 2, 3)
Name Description	Remodel the Structure of Chromatin 1

GO Annotations	All RSC6 GO evidence and references
	View Computational GO annotations for RSC6
Molecular Function
Manually curated	contributes_to DNA-dependent ATPase activity (IDA)
Biological Process
Manually curated	ATP-dependent chromatin remodeling (IDA) G2/M transition of mitotic cell cycle (IMP) nucleosome disassembly (IDA) RNA elongation from RNA polymerase II promoter (IDA)
Cellular Component
Manually curated	RSC complex (IDA)

Mutant Phenotype	All RSC6 Phenotype details and references
Classical genetics
repressible	cell cycle progression through the G2/M phase transition: arrested Pmp2GFP-KKTN distribution: decreased
Large-scale survey
conditional	heat sensitivity: increased
null	competitive fitness: decreased haploinsufficient inviable resistance to sulfanilamide: decreased
repressible	Pmp2GFP-LRKR distribution: decreased

Interactions	RSC6 All interactions details and references
	191 total interaction(s) for 111 unique genes/features.
Physical Interactions	Affinity Capture-MS: 85 Affinity Capture-Western: 10 Biochemical Activity: 1 Co-purification: 2 Reconstituted Complex: 1 Two-hybrid: 4
Genetic Interactions	Dosage Rescue: 1 Phenotypic Enhancement: 44 Phenotypic Suppression: 41 Synthetic Growth Defect: 2

Sequence Information

ChrIII:214990 to 216441 | |

Last Update

Coordinates: 2006-01-12 | Sequence: 1997-01-28

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1452	214990..216441	2006-01-12	1997-01-28

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000000648

RSC6 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for RSC6

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for RSC6]

1)	Cairns BR, et al. (1996) RSC, an essential, abundant chromatin-remodeling complex. Cell 87(7):1249-60
2)	Lorch Y, et al. (1998) Activated RSC-nucleosome complex and persistently altered form of the nucleosome. Cell 94(1):29-34
3)	Neely KE and Workman JL (2002) The complexity of chromatin remodeling and its links to cancer. Biochim Biophys Acta 1603(1):19-29

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