PER1/YCR044C Summary Help

Standard Name PER1 1
Systematic Name YCR044C
Alias COS16 2
Feature Type ORF, Verified
Description Protein of the endoplasmic reticulum; required for GPI-phospholipase A2 activity that remodels the GPI anchor as a prerequisite for association of GPI-anchored proteins with lipid rafts; functionally complemented by human ortholog PERLD1 (1)
Name Description protein Processing in the ER 3
Chromosomal Location
ChrIII:207950 to 206877 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All PER1 GO evidence and references
  View Computational GO annotations for PER1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 6 genes
Resources
Classical genetics
null
reduction of function
Large-scale survey
null
overexpression
Resources
315 total interaction(s) for 187 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 6
  • Affinity Capture-RNA: 2
  • PCA: 2

Genetic Interactions
  • Negative Genetic: 161
  • Phenotypic Enhancement: 5
  • Phenotypic Suppression: 72
  • Positive Genetic: 35
  • Synthetic Growth Defect: 22
  • Synthetic Lethality: 3
  • Synthetic Rescue: 7

Resources
Expression Summary
histogram
Resources
Length (a.a.) 357
Molecular Weight (Da) 42,541
Isoelectric Point (pI) 6.85
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIII:207950 to 206877 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1074 207950..206877 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000640
References cited on this page View Complete Literature Guide for PER1
1) Fujita M, et al.  (2006) PER1 Is Required for GPI-Phospholipase A2 Activity and Involved in Lipid Remodeling of GPI-anchored Proteins. Mol Biol Cell 17(12):5253-64
2) Paidhungat M and Garrett S  (1998) Cdc1 and the vacuole coordinately regulate Mn2+ homeostasis in the yeast Saccharomyces cerevisiae. Genetics 148(4):1787-98
3) Ng DT, et al.  (2000) The unfolded protein response regulates multiple aspects of secretory and membrane protein biogenesis and endoplasmic reticulum quality control. J Cell Biol 150(1):77-88