ELO2/YCR034W Summary Help

Standard Name ELO2 1
Systematic Name YCR034W
Alias GNS1 2 , VBM2 3 , FEN1 4
Feature Type ORF, Verified
Description Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway; FEN1 has a paralog, ELO1, that arose from the whole genome duplication (1, 3, 5, 6, 7)
Name Description fatty acid ELOngation 1
Chromosomal Location
ChrIII:190592 to 191635 | ORF Map | GBrowse
Gbrowse
Genetic position: 24 cM
Gene Ontology Annotations All ELO2 GO evidence and references
  View Computational GO annotations for ELO2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 11 genes
Resources
Pathways
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
301 total interaction(s) for 258 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 6
  • Affinity Capture-Western: 1
  • PCA: 65
  • Protein-RNA: 1
  • Reconstituted Complex: 1

Genetic Interactions
  • Dosage Growth Defect: 1
  • Negative Genetic: 104
  • Phenotypic Enhancement: 1
  • Positive Genetic: 90
  • Synthetic Growth Defect: 12
  • Synthetic Lethality: 11
  • Synthetic Rescue: 8

Resources
Expression Summary
histogram
Resources
Length (a.a.) 347
Molecular Weight (Da) 40,002
Isoelectric Point (pI) 10.35
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIII:190592 to 191635 | ORF Map | GBrowse
SGD ORF map
Genetic position: 24 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1044 190592..191635 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000630
References cited on this page View Complete Literature Guide for ELO2
1) Oh CS, et al.  (1997) ELO2 and ELO3, homologues of the Saccharomyces cerevisiae ELO1 gene, function in fatty acid elongation and are required for sphingolipid formation. J Biol Chem 272(28):17376-84
2) Rieger KJ, et al.  (1997) Large-scale phenotypic analysis--the pilot project on yeast chromosome III. Yeast 13(16):1547-62
3) David D, et al.  (1998) Involvement of long chain fatty acid elongation in the trafficking of secretory vesicles in yeast. J Cell Biol 143(5):1167-82
4) Ladeveze V, et al.  (1993) General resistance to sterol biosynthesis inhibitors in Saccharomyces cerevisiae. Lipids 28(10):907-12
5) Abe M, et al.  (2001) Yeast 1,3-beta-glucan synthase activity is inhibited by phytosphingosine localized to the endoplasmic reticulum. J Biol Chem 276(29):26923-30
6) Chung JH, et al.  (2003) Sphingolipid requirement for generation of a functional v1 component of the vacuolar ATPase. J Biol Chem 278(31):28872-81
7) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61