SYP1/YCR030C Summary Help

Standard Name SYP1 1
Systematic Name YCR030C
Alias YCR029C-A
Feature Type ORF, Verified
Description Negative regulator of WASP-Arp23 complex; involved in endocytic site formation; directly inhibits Las17p stimulation of Arp23 complex-mediated actin assembly in vitro; may regulate assembly and disassembly of the septin ring; colocalizes and interacts with septin subunits; potential role in actin cytoskeletal organization (1, 2, 3, 4)
Name Description Suppressor of Yeast Profilin deletion 1
Chromosomal Location
ChrIII:176438 to 173826 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All SYP1 GO evidence and references
  View Computational GO annotations for SYP1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 2 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
84 total interaction(s) for 59 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 25
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 5
  • Biochemical Activity: 1
  • Co-crystal Structure: 1
  • Co-localization: 1
  • Co-purification: 1
  • PCA: 21
  • Reconstituted Complex: 2
  • Two-hybrid: 6

Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 5
  • Negative Genetic: 9
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 1
  • Synthetic Lethality: 1
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 870
Molecular Weight (Da) 96,137
Isoelectric Point (pI) 9.17
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIII:176438 to 173826 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2000-09-13
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2613 176438..173826 2011-02-03 2000-09-13
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000626
References cited on this page View Complete Literature Guide for SYP1
1) Marcoux N, et al.  (2000) Suppression of the profilin-deficient phenotype by the RHO2 signaling pathway in Saccharomyces cerevisiae. Genetics 156(2):579-92
2) Qiu W, et al.  (2008) A novel septin-associated protein, syp1p, is required for normal cell cycle-dependent septin cytoskeleton dynamics in yeast. Genetics 180(3):1445-57
3) Stimpson HE, et al.  (2009) Early-arriving Syp1p and Ede1p function in endocytic site placement and formation in budding yeast. Mol Biol Cell 20(22):4640-51
4) Boettner DR, et al.  (2009) The F-BAR protein Syp1 negatively regulates WASp-Arp2/3 complex activity during endocytic patch formation. Curr Biol 19(23):1979-87