Standard Name	FEN2
Systematic Name	YCR028C
Feature Type	ORF, Verified
Description	Plasma membrane H+-pantothenate symporter; confers sensitivity to the antifungal agent fenpropimorph; relocalizes from vacuole to cytoplasm upon DNA replication stress (1, 2)
Name Description	FENpropimorph resistance

Chromosomal Location	ChrIII:172424 to 170886 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for FEN2
Molecular Function
Manually curated	pantothenate transmembrane transporter activity (IGI, IMP)
Biological Process
Manually curated	endocytosis (IMP) pantothenate transmembrane transport (IGI, IMP)
Cellular Component
Manually curated	plasma membrane (IGI, ISS)
High-throughput	fungal-type vacuole membrane (IDA) integral to membrane (ISM)

Classical genetics
null	chromosome/plasmid maintenance: abnormal endocytosis: decreased
Large-scale survey
null	acid pH resistance: decreased glycogen accumulation: increased proton accumulation: decreased competitive fitness: decreased dessication resistance: decreased endocytosis: decreased haploinsufficient heat sensitivity: increased resistance to streptomycin: decreased resistance to cycloheximide: decreased resistance to fluconazole: decreased resistance to sodium arsenite: decreased resistance to mefloquine: decreased resistance to mycophenolic acid: decreased resistance to L-1,4-dithiothreitol: decreased resistance to caffeine: decreased resistance to sorbate: decreased resistance to doxorubicin: decreased resistance to hygromycin B: decreased stress resistance: increased toxin resistance: decreased vegetative growth: decreased rate viable
overexpression	resistance to sirolimus: decreased vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	40 total interaction(s) for 38 unique genes/features.
Physical Interactions	PCA: 6 Reconstituted Complex: 1 Two-hybrid: 1
Genetic Interactions	Dosage Lethality: 1 Negative Genetic: 12 Positive Genetic: 11 Synthetic Lethality: 6 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIII:172424 to 170886 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	This feature is contained within: 70145
	This feature is contained within: 70885
Last Update	Coordinates: 2011-02-03 | Sequence: 2000-09-13
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1539 172424..170886 2011-02-03 2000-09-13
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB

Primary SGDID	S000000623