HSP30/YCR021C Summary Help

Standard Name HSP30 1
Systematic Name YCR021C
Alias YRO1
Feature Type ORF, Verified
Description Negative regulator of the H(+)-ATPase Pma1p; stress-responsive protein; hydrophobic plasma membrane localized; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase (1, 2, 3, 4, 5, 6)
Name Description Heat Shock Protein 1, 2
Chromosomal Location
ChrIII:157107 to 156109 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gene Ontology Annotations All HSP30 GO evidence and references
  View Computational GO annotations for HSP30
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 68 genes
Classical genetics
Large-scale survey
100 total interaction(s) for 88 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 2
  • PCA: 30
  • Two-hybrid: 1

Genetic Interactions
  • Negative Genetic: 60
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 1
  • Positive Genetic: 2
  • Synthetic Rescue: 1

Expression Summary
Length (a.a.) 332
Molecular Weight (Da) 37,044
Isoelectric Point (pI) 4.96
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrIII:157107 to 156109 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..999 157107..156109 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB
Primary SGDIDS000000615
References cited on this page View Complete Literature Guide for HSP30
1) Panaretou B and Piper PW  (1992) The plasma membrane of yeast acquires a novel heat-shock protein (hsp30) and displays a decline in proton-pumping ATPase levels in response to both heat shock and the entry to stationary phase. Eur J Biochem 206(3):635-40
2) Regnacq M and Boucherie H  (1993) Isolation and sequence of HSP30, a yeast heat-shock gene coding for a hydrophobic membrane protein. Curr Genet 23(5-6):435-42
3) Seymour IJ and Piper PW  (1999) Stress induction of HSP30, the plasma membrane heat shock protein gene of Saccharomyces cerevisiae, appears not to use known stress-regulated transcription factors. Microbiology 145 ( Pt 1)():231-9
4) Piper PW, et al.  (1997) Hsp30, the integral plasma membrane heat shock protein of Saccharomyces cerevisiae, is a stress-inducible regulator of plasma membrane H(+)-ATPase. Cell Stress Chaperones 2(1):12-24
5) Piper PW, et al.  (1994) Induction of major heat-shock proteins of Saccharomyces cerevisiae, including plasma membrane Hsp30, by ethanol levels above a critical threshold. Microbiology 140 ( Pt 11)():3031-8
6) Meena RC, et al.  (2011) Regulation of Saccharomyces cerevisiae Plasma membrane H+-ATPase (Pma1) by Dextrose and Hsp30 during Exposure to Thermal Stress Indian J Microbiol 51(2):153-158