RVS161/YCR009C Summary Help

RVS161 BASIC INFORMATION

Standard Name RVS161 1
Systematic Name YCR009C
Alias END6 2 , FUS7 3 , SPE161
Feature Type ORF, Verified
Description Amphiphysin-like lipid raft protein; interacts with Rvs167p and regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress (1, 2, 4, 5, 6, 7)
Name Description Reduced Viability on Starvation 1, 8
GO Annotations All RVS161 GO evidence and references
    View Computational GO annotations for RVS161
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant Phenotype All RVS161 Phenotype details and references
Classical genetics
null
reduction of function
Large-scale survey
null
Interactions RVS161 All interactions details and references
354 total interaction(s) for 213 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 38
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 3
  • Co-fractionation: 2
  • PCA: 3
  • Reconstituted Complex: 1
  • Two-hybrid: 33
Genetic Interactions
  • Dosage Lethality: 2
  • Dosage Rescue: 5
  • Phenotypic Enhancement: 79
  • Phenotypic Suppression: 17
  • Synthetic Growth Defect: 55
  • Synthetic Lethality: 107
  • Synthetic Rescue: 8
Sequence Information
ChrIII:131540 to 130743 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: 1 cM
Last Update Coordinates: 2006-01-12 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..798 131540..130743 2006-01-12 1997-01-28
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000000602

RVS161 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Literature
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  • Protein Info & Structure
  • Localization Resources
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  • Phenotype Resources
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  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for RVS161

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for RVS161]

1) Crouzet M, et al.  (1991) Yeast mutant affected for viability upon nutrient starvation: characterization and cloning of the RVS161 gene. Yeast 7(7):727-43
2) Munn AL, et al.  (1995) end5, end6, and end7: mutations that cause actin delocalization and block the internalization step of endocytosis in Saccharomyces cerevisiae. Mol Biol Cell 6(12):1721-42
3) Gammie AE, et al.  (1998) Distinct morphological phenotypes of cell fusion mutants. Mol Biol Cell 9(6):1395-410
4) Navarro P, et al.  (1997) Protein-protein interaction between the RVS161 and RVS167 gene products of Saccharomyces cerevisiae. Biochim Biophys Acta 1343(2):187-92
5) Sivadon P, et al.  (1995) Actin cytoskeleton and budding pattern are altered in the yeast rvs161 mutant: the Rvs161 protein shares common domains with the brain protein amphiphysin. Mol Gen Genet 246(4):485-95
6) Brizzio V, et al.  (1998) Rvs161p interacts with Fus2p to promote cell fusion in Saccharomyces cerevisiae. J Cell Biol 141(3):567-84
7) Lombardi R and Riezman H  (2001) Rvs161p and Rvs167p, the two yeast amphiphysin homologs, function together in vivo. J Biol Chem 276(8):6016-22
8) Bauer F, et al.  (1993) Alteration of a yeast SH3 protein leads to conditional viability with defects in cytoskeletal and budding patterns. Mol Cell Biol 13(8):5070-84