GEX1/YCL073C Summary Help

Standard Name GEX1 1
Systematic Name YCL073C
Feature Type ORF, Verified
Description Proton:glutathione antiporter; localized to the vacuolar and plasma membranes; imports glutathione from the vacuole and exports it through the plasma membrane; has a role in resistance to oxidative stress and modulation of the PKA pathway; GEX1 has a paralog, GEX2, that arose from a segmental duplication (1, 2, 3)
Name Description Glutathione EXchanger 1
Chromosomal Location
ChrIII:8326 to 6479 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All GEX1 GO evidence and references
  View Computational GO annotations for GEX1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 2 genes
Resources
Classical genetics
overexpression
Large-scale survey
overexpression
Resources
2 total interaction(s) for 2 unique genes/features.
Physical Interactions
  • PCA: 1
  • Two-hybrid: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 615
Molecular Weight (Da) 68,920
Isoelectric Point (pI) 9.39
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIII:8326 to 6479 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2000-09-13 | Sequence: 2000-09-13
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1848 8326..6479 2000-09-13 2000-09-13
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB
Primary SGDIDS000000575
References cited on this page View Complete Literature Guide for GEX1
1) Dhaoui M, et al.  (2011) Gex1 is a yeast glutathione exchanger that interferes with pH and redox homeostasis. Mol Biol Cell 22(12):2054-67
2) Gromadka R, et al.  (1996) Subtelomeric duplications in Saccharomyces cerevisiae chromosomes III and XI: topology, arrangements, corrections of sequence and strain-specific polymorphism. Yeast 12(6):583-91
3) Katju V, et al.  (2009) Variation in gene duplicates with low synonymous divergence in Saccharomyces cerevisiae relative to Caenorhabditis elegans. Genome Biol 10(7):R75