PRD1/YCL057W Summary Help

Standard Name PRD1 1
Systematic Name YCL057W
Feature Type ORF, Verified
Description Zinc metalloendopeptidase; found in the cytoplasm and intermembrane space of mitochondria; with Cym1p, involved in degradation of mitochondrial proteins and of presequence peptides cleaved from imported proteins; protein abundance increases in response to DNA replication stress (2, 3, 4, 5)
Name Description PRoteinase yscD 1
Chromosomal Location
ChrIII:24768 to 26906 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All PRD1 GO evidence and references
  View Computational GO annotations for PRD1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 2 genes
Resources
Large-scale survey
null
Resources
9 total interaction(s) for 6 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 712
Molecular Weight (Da) 81,933
Isoelectric Point (pI) 5.6
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIII:24768 to 26906 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2000-09-13 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2139 24768..26906 2000-09-13 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000562
References cited on this page View Complete Literature Guide for PRD1
1) Garcia-Alvarez N, et al.  (1987) Proteinase yscD mutants of yeast. Isolation and characterization. Eur J Biochem 163(2):339-46
2) Buchler M, et al.  (1994) Proteinase yscD (oligopeptidase yscD). Structure, function and relationship of the yeast enzyme with mammalian thimet oligopeptidase (metalloendopeptidase, EP 24.15). Eur J Biochem 219(1-2):627-39
3) Hrycyna CA and Clarke S  (1993) Purification and characterization of a novel metalloendopeptidase from Saccharomyces cerevisiae. Biochemistry 32(42):11293-301
4) Kambacheld M, et al.  (2005) Role of the novel metallopeptidase Mop112 and saccharolysin for the complete degradation of proteins residing in different subcompartments of mitochondria. J Biol Chem 280(20):20132-9
5) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76