Standard Name	KAR4 1
Systematic Name	YCL055W
Feature Type	ORF, Verified
Description	Transcription factor required for gene regulation in response to pheromones; also required during meiosis; exists in two forms, a slower-migrating form more abundant during vegetative growth and a faster-migrating form induced by pheromone (2, 3, 4)
Name Description	KARyogamy

Chromosomal Location	ChrIII:27929 to 28936 | ORF Map | GBrowse

	View Computational GO annotations for KAR4
Molecular Function
Manually curated	sequence-specific DNA binding transcription factor activity (IDA, IGI, IMP)
Biological Process
Manually curated	G1 phase of mitotic cell cycle (IEP, IMP) karyogamy involved in conjugation with cellular fusion (IMP) meiosis (IMP) negative regulation of transcription from RNA polymerase II promoter by pheromones (IEP) positive regulation of transcription from RNA polymerase II promoter by pheromones (IDA, IEP, IGI, IMP)
Cellular Component
High-throughput	cytoplasm (IDA) nucleus (IDA)

Regulatory modules	predicted: stressResponse (613)
Resources	YEASTRACT | YeTFaSCo

Classical genetics
reduction of function	cytoskeleton morphology: abnormal nuclear fusion during mating: abnormal
Large-scale survey
null	competitive fitness: decreased sporulation: decreased sporulation efficiency: decreased starvation resistance: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	32 total interaction(s) for 31 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 2 PCA: 2 Two-hybrid: 4
Genetic Interactions	Negative Genetic: 18 Phenotypic Suppression: 1 Positive Genetic: 4 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIII:27929 to 28936 | ORF Map | GBrowse
Last Update	Coordinates: 2000-09-13 | Sequence: 1997-01-28
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1008 27929..28936 2000-09-13 1997-01-28
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000560