SRO9/YCL037C Summary

SRO9 BASIC INFORMATION

Standard Name	SRO9 1
Systematic Name	YCL037C
Feature Type	ORF, Verified
Description	Cytoplasmic RNA-binding protein that associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif (1, 2, 3)
Name Description	Suppressor of rho3 1

GO Annotations	All SRO9 GO evidence and references
	View Computational GO annotations for SRO9
Molecular Function
Manually curated	RNA binding (IDA)
Biological Process
Manually curated	translation (IPI)
Cellular Component
Manually curated	polysome (IDA)

Mutant Phenotype	All SRO9 Phenotype details and references
Large-scale survey
null	UV resistance: decreased competitive fitness: decreased fermentative growth: decreased rate haploinsufficient resistance to cisplatin: decreased transposable element transposition: increased viable

Interactions	SRO9 All interactions details and references
	185 total interaction(s) for 143 unique genes/features.
Physical Interactions	Affinity Capture-MS: 44 Affinity Capture-RNA: 1 Affinity Capture-Western: 4 Biochemical Activity: 1 PCA: 12
Genetic Interactions	Dosage Rescue: 5 Phenotypic Enhancement: 75 Phenotypic Suppression: 23 Synthetic Growth Defect: 11 Synthetic Lethality: 9

Sequence Information

ChrIII:58678 to 57374 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2003-09-22 | Sequence: 2003-09-22

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1305	58678..57374	2003-09-22	2003-09-22

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000000542

SRO9 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for SRO9

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SRO9]

1)	Kagami M, et al. (1997) SRO9, a multicopy suppressor of the bud growth defect in the Saccharomyces cerevisiae rho3-deficient cells, shows strong genetic interactions with tropomyosin genes, suggesting its role in organization of the actin cytoskeleton. Genetics 147(3):1003-16
2)	Sobel SG and Wolin SL (1999) Two yeast La motif-containing proteins are RNA-binding proteins that associate with polyribosomes. Mol Biol Cell 10(11):3849-62
3)	Hon T, et al. (2001) The Hsp70-Ydj1 molecular chaperone represses the activity of the heme activator protein Hap1 in the absence of heme. Mol Cell Biol 21(23):7923-32

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