Standard Name	GRX1
Systematic Name	YCL035C
Feature Type	ORF, Verified
Description	Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress (1, 2, 3, 4)
Name Description	GlutaRedoXin 1

Chromosomal Location	ChrIII:61173 to 60841 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for GRX1
Molecular Function
Manually curated	disulfide oxidoreductase activity (ISS) glutathione peroxidase activity (IDA) glutathione transferase activity (IDA)
Biological Process
Manually curated	cellular response to oxidative stress (IMP) protein glutathionylation (IGI)
Cellular Component
High-throughput	cytoplasm (IDA) nucleus (IDA)

Pathways	glutathione-glutaredoxin system

Classical genetics
null	oxidative stress resistance: increased resistance to 2,4-D: decreased
overexpression	resistance to hydrogen peroxide: increased
Large-scale survey
null	competitive fitness: decreased hyperosmotic stress resistance: decreased resistance to sodium selenide: decreased starvation resistance: decreased vacuolar morphology: abnormal vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	36 total interaction(s) for 34 unique genes/features.
Physical Interactions	Affinity Capture-MS: 5 Affinity Capture-RNA: 3 PCA: 1 Reconstituted Complex: 4 Two-hybrid: 1
Genetic Interactions	Negative Genetic: 4 Phenotypic Enhancement: 2 Positive Genetic: 7 Synthetic Growth Defect: 3 Synthetic Lethality: 3 Synthetic Rescue: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIII:61173 to 60841 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2000-09-13 | Sequence: 1997-01-28
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..333 61173..60841 2000-09-13 1997-01-28
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000540