Standard Name	FUS1 1
Systematic Name	YCL027W
Feature Type	ORF, Verified
Description	Membrane protein localized to the shmoo tip, required for cell fusion; expression regulated by mating pheromone; proposed to coordinate signaling, fusion, and polarization events required for fusion; potential Cdc28p substrate (1, 2, 3, 4)
Name Description	cell FUSion 1

Chromosomal Location	ChrIII:71803 to 73341 | ORF Map | GBrowse
	Genetic position: -21 cM

	View Computational GO annotations for FUS1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	cortical protein anchoring (IMP) cytogamy (IGI, IMP) regulation of termination of mating projection growth (IMP)
Cellular Component
Manually curated	integral to plasma membrane (IDA) mating projection tip (IDA)
High-throughput	mating projection tip (IDA)

Classical genetics
null	SLT2-LacZ accumulation: decreased cell fusion: decreased calcium(2+) accumulation: decreased mating efficiency: decreased necrotic cell death: decreased nuclear fusion during mating: delayed Fus2p-GFP distribution: abnormal shmoo formation: abnormal
Large-scale survey
null	anaerobic growth: decreased competitive fitness: increased filamentous growth: increased resistance to amitrole: decreased resistance to cycloheximide: decreased resistance to streptomycin: decreased sporulation: decreased viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	76 total interaction(s) for 50 unique genes/features.
Physical Interactions	Affinity Capture-MS: 3 Affinity Capture-RNA: 1 Affinity Capture-Western: 1 Biochemical Activity: 1 Co-localization: 2 PCA: 4 Protein-peptide: 2 Reconstituted Complex: 1 Two-hybrid: 35
Genetic Interactions	Dosage Growth Defect: 2 Dosage Rescue: 9 Phenotypic Enhancement: 12 Synthetic Growth Defect: 1 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIII:71803 to 73341 | ORF Map | GBrowse
	This feature contains embedded feature(s): YCLX07W
	Genetic position: -21 cM
Last Update	Coordinates: 2000-09-13 | Sequence: 2000-09-13
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1539 71803..73341 2000-09-13 2000-09-13
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000532