FUS1/YCL027W Summary

FUS1 BASIC INFORMATION

Standard Name	FUS1 1
Systematic Name	YCL027W
Feature Type	ORF, Verified
Description	Membrane protein localized to the shmoo tip, required for cell fusion; expression regulated by mating pheromone; proposed to coordinate signaling, fusion, and polarization events required for fusion; potential Cdc28p substrate (1, 2, 3, 4)
Name Description	cell FUSion 1

GO Annotations	All FUS1 GO evidence and references
	View Computational GO annotations for FUS1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	cortical protein anchoring (IMP) cytogamy (IGI, IMP) regulation of termination of mating projection growth (IMP)
Cellular Component
Manually curated	integral to plasma membrane (IDA) mating projection tip (IDA)
High-throughput	mating projection tip (IDA)

Mutant Phenotype	All FUS1 Phenotype details and references
Classical genetics
null	cell fusion: decreased mating efficiency: decreased nuclear fusion during mating: delayed Fus2p-GFP distribution: abnormal shmoo formation: abnormal
Large-scale survey
null	filamentous growth: increased sporulation: decreased viable

Interactions	FUS1 All interactions details and references
	66 total interaction(s) for 42 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 1 Affinity Capture-Western: 1 Biochemical Activity: 2 Co-localization: 2 Protein-peptide: 2 Reconstituted Complex: 1 Two-hybrid: 39
Genetic Interactions	Dosage Rescue: 9 Phenotypic Enhancement: 8 Synthetic Rescue: 1

Sequence Information

ChrIII:71803 to 73341 | |

This feature contains embedded feature(s): YCLX07W

Genetic position: -21 cM

Last Update

Coordinates: 2000-09-13 | Sequence: 2000-09-13

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1539	71803..73341	2000-09-13	2000-09-13

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000000532

FUS1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for FUS1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for FUS1]

1)	Trueheart J, et al. (1987) Two genes required for cell fusion during yeast conjugation: evidence for a pheromone-induced surface protein. Mol Cell Biol 7(7):2316-28
2)	Bagnat M and Simons K (2002) Cell surface polarization during yeast mating. Proc Natl Acad Sci U S A 99(22):14183-8
3)	Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
4)	Nelson B, et al. (2004) Fus1p interacts with components of the Hog1p mitogen-activated protein kinase and Cdc42p morphogenesis signaling pathways to control cell fusion during yeast mating. Genetics 166(1):67-77

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