Standard Name	AGP1
Systematic Name	YCL025C
Alias	YCC5
Feature Type	ORF, Verified
Description	Low-affinity amino acid permease with broad substrate range; involved in uptake of asparagine, glutamine, and other amino acids; expression regulated by SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p); AGP1 has a paralog, GNP1, that arose from the whole genome duplication (1, 2, 3)
Name Description	high-Affinity Glutamine Permease 1

Chromosomal Location	ChrIII:77919 to 76018 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for AGP1
Molecular Function
Manually curated	amino acid transmembrane transporter activity (IDA) L-proline transmembrane transporter activity (IGI)
Biological Process
Manually curated	amino acid transport (IDA) transmembrane transport (IDA)
Cellular Component
Manually curated	plasma membrane (ISS)
High-throughput	integral to membrane (ISM)

Classical genetics
null	glycogen accumulation: increased chronological lifespan: increased resistance to quinine: increased
Large-scale survey
null	competitive fitness: increased haploproficient resistance to cycloheximide: decreased resistance to camptothecin: increased resistance to quinine: increased resistance to fenpropimorph: decreased resistance to fluconazole: decreased resistance to methyl methanesulfonate: decreased resistance to tunicamycin: decreased resistance to hydroxyurea: increased viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	142 total interaction(s) for 120 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 Affinity Capture-RNA: 1 PCA: 36
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 77 Phenotypic Enhancement: 1 Positive Genetic: 17 Synthetic Growth Defect: 7 Synthetic Lethality: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIII:77919 to 76018 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	This feature contains embedded feature(s): YCLX09W
Last Update	Coordinates: 2006-01-12 | Sequence: 2006-01-12
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1902 77919..76018 2006-01-12 2006-01-12
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB

Primary SGDID	S000000530