KCC4/YCL024W Summary

KCC4 BASIC INFORMATION

Standard Name	KCC4
Systematic Name	YCL024W
Feature Type	ORF, Verified
Description	Protein kinase of the bud neck involved in the septin checkpoint, associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p (1, 2, 3)

GO Annotations	All KCC4 GO evidence and references
	View Computational GO annotations for KCC4
Molecular Function
Manually curated	protein kinase activity (ISS)
Biological Process
Manually curated	budding cell bud growth (IGI, IMP) protein amino acid phosphorylation (ISS) septin checkpoint (IGI, IMP) septin ring assembly (IGI, IMP)
Cellular Component
Manually curated	cellular bud neck (IDA) cellular bud neck septin collar (IDA) incipient cellular bud site (IDA) septin ring (IDA)

Regulatory Role
Regulatory modules	predicted: cellcycle ( 383 , 251 )

Mutant Phenotype	All KCC4 Phenotype details and references
Large-scale survey
null	viable

Interactions	KCC4 All interactions details and references
	39 total interaction(s) for 32 unique genes/features.
Physical Interactions	Affinity Capture-MS: 7 Affinity Capture-Western: 5 Biochemical Activity: 10 Reconstituted Complex: 1 Two-hybrid: 4
Genetic Interactions	Phenotypic Enhancement: 7 Phenotypic Suppression: 4 Synthetic Rescue: 1

Sequence Information

ChrIII:79162 to 82275 | |

This feature contains embedded feature(s): YCL022C

Last Update

Coordinates: 2006-01-12 | Sequence: 2000-09-13

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..3114	79162..82275	2006-01-12	2000-09-13

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000000529

KCC4 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for KCC4

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for KCC4]

1)	Barral Y, et al. (1999) Nim1-related kinases coordinate cell cycle progression with the organization of the peripheral cytoskeleton in yeast. Genes Dev 13(2):176-87
2)	Okuzaki D and Nojima H (2001) Kcc4 associates with septin proteins of Saccharomyces cerevisiae. FEBS Lett 489(2-3):197-201
3)	Okuzaki D, et al. (2003) The Saccharomyces cerevisiae bud-neck proteins Kcc4 and Gin4 have distinct but partially-overlapping cellular functions. Genes Genet Syst 78(2):113-26

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