Standard Name	KCC4
Systematic Name	YCL024W
Feature Type	ORF, Verified
Description	Protein kinase of the bud neck involved in the septin checkpoint; associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p; KCC4 has a paralog, GIN4, that arose from the whole genome duplication (1, 2, 3, 4)

Chromosomal Location	ChrIII:79162 to 82275 | ORF Map | GBrowse

	View Computational GO annotations for KCC4
Molecular Function
Manually curated	phosphatidic acid binding (IDA) phosphatidylinositol-4,5-bisphosphate binding (IDA) phosphatidylserine binding (IDA) protein kinase activity (ISS)
High-throughput	protein kinase activity (IDA)
Biological Process
Manually curated	budding cell bud growth (IGI, IMP) protein phosphorylation (ISS) septin checkpoint (IGI, IMP) septin ring assembly (IGI, IMP)
High-throughput	protein phosphorylation (IDA)
Cellular Component
Manually curated	cellular bud neck (IDA) cellular bud neck septin collar (IDA) incipient cellular bud site (IDA) plasma membrane (IDA) septin ring (IDA)

Regulatory modules	predicted: cellcycle (383, 251)

Classical genetics
null	cellular morphology: abnormal resistance to sodium dodecyl sulfate: increased
overexpression	cellular morphology: abnormal colony size: decreased
Large-scale survey
null	competitive fitness: decreased resistance to benzo[a]pyrene: increased resistance to benzo[a]pyrene: decreased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	113 total interaction(s) for 85 unique genes/features.
Physical Interactions	Affinity Capture-MS: 18 Affinity Capture-Western: 6 Biochemical Activity: 10 PCA: 11 Reconstituted Complex: 24 Two-hybrid: 4
Genetic Interactions	Dosage Growth Defect: 1 Dosage Lethality: 1 Negative Genetic: 29 Positive Genetic: 5 Synthetic Lethality: 3 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIII:79162 to 82275 | ORF Map | GBrowse
	This feature contains embedded feature(s): YCL022C
Last Update	Coordinates: 2006-01-12 | Sequence: 2000-09-13
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..3114 79162..82275 2006-01-12 2000-09-13
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000529