PGS1/YCL004W Summary Help

Standard Name PGS1 1
Systematic Name YCL004W
Alias PEL1 2 , YCL003W
Feature Type ORF, Verified
Description Phosphatidylglycerolphosphate synthase; catalyzes the synthesis of phosphatidylglycerolphosphate from CDP-diacylglycerol and sn-glycerol 3-phosphate in the first committed and rate-limiting step of cardiolipin biosynthesis (1, 2)
Name Description PhosphatidylGlycerolphosphate Synthase 1
Chromosomal Location
ChrIII:109105 to 110670 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All PGS1 GO evidence and references
  View Computational GO annotations for PGS1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 113 genes
Resources
Pathways
Classical genetics
null
unspecified
Large-scale survey
null
reduction of function
unspecified
Resources
49 total interaction(s) for 46 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 2

Genetic Interactions
  • Negative Genetic: 10
  • Phenotypic Suppression: 2
  • Positive Genetic: 3
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 6
  • Synthetic Rescue: 23

Resources
Expression Summary
histogram
Resources
Length (a.a.) 521
Molecular Weight (Da) 59,370
Isoelectric Point (pI) 10.5
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIII:109105 to 110670 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2006-01-12 | Sequence: 2000-02-10
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1566 109105..110670 2006-01-12 2000-02-10
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000510
References cited on this page View Complete Literature Guide for PGS1
1) Chang SC, et al.  (1998) The PEL1 gene (renamed PGS1) encodes the phosphatidylglycero-phosphate synthase of Saccharomyces cerevisiae. J Biol Chem 273(16):9829-36
2) Janitor M and Subik J  (1993) Molecular cloning of the PEL1 gene of Saccharomyces cerevisiae that is essential for the viability of petite mutants. Curr Genet 24(4):307-12