PGS1/YCL004W Summary Help

Standard Name PGS1 1
Systematic Name YCL004W
Alias PEL1 2 , YCL003W
Feature Type ORF, Verified
Description Phosphatidylglycerolphosphate synthase; catalyzes the synthesis of phosphatidylglycerolphosphate from CDP-diacylglycerol and sn-glycerol 3-phosphate in the first committed and rate-limiting step of cardiolipin biosynthesis (1, 2)
Name Description PhosphatidylGlycerolphosphate Synthase 1
Chromosomal Location
ChrIII:109105 to 110670 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All PGS1 GO evidence and references
  View Computational GO annotations for PGS1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 1 genes
Resources
Pathways
Classical genetics
null
unspecified
Large-scale survey
null
reduction of function
unspecified
Resources
49 total interaction(s) for 46 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 2

Genetic Interactions
  • Negative Genetic: 10
  • Phenotypic Suppression: 2
  • Positive Genetic: 3
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 6
  • Synthetic Rescue: 23

Resources
Expression Summary
histogram
Resources
Length (a.a.) 521
Molecular Weight (Da) 59,370
Isoelectric Point (pI) 10.5
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIII:109105 to 110670 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2006-01-12 | Sequence: 2000-02-10
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1566 109105..110670 2006-01-12 2000-02-10
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000510
References cited on this page View Complete Literature Guide for PGS1
1) Chang SC, et al.  (1998) The PEL1 gene (renamed PGS1) encodes the phosphatidylglycero-phosphate synthase of Saccharomyces cerevisiae. J Biol Chem 273(16):9829-36
2) Janitor M and Subik J  (1993) Molecular cloning of the PEL1 gene of Saccharomyces cerevisiae that is essential for the viability of petite mutants. Curr Genet 24(4):307-12