Standard Name	PGS1 1
Systematic Name	YCL004W
Alias	PEL1 2 , YCL003W
Feature Type	ORF, Verified
Description	Phosphatidylglycerolphosphate synthase, catalyzes the synthesis of phosphatidylglycerolphosphate from CDP-diacylglycerol and sn-glycerol 3-phosphate in the first committed and rate-limiting step of cardiolipin biosynthesis (1, 2)
Name Description	PhosphatidylGlycerolphosphate Synthase 1

Chromosomal Location	ChrIII:109105 to 110670 | ORF Map | GBrowse

	View Computational GO annotations for PGS1
Molecular Function
Manually curated	CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity (IMP)
Biological Process
Manually curated	cardiolipin biosynthetic process (IMP)
Cellular Component
Manually curated	mitochondrion (IDA)

Pathways	phosphatidic acid and phospholipid biosynthesis phospholipid biosynthesis superpathway of phospholipid biosynthesis

Classical genetics
null	phosphatidic acid accumulation: increased phosphatidylinositol accumulation: increased CDP-diacylglycerol accumulation: increased cardiolipin accumulation: decreased heat sensitivity: increased mitochondrial morphology: abnormal petite-negative resistance to fluconazole: increased resistance to 4-Nitroquinoline N-oxide: decreased resistance to oligomycin: decreased resistance to chloramphenicol: decreased resistance to ketoconazole: decreased resistance to miconazole: decreased resistance to clotrimazole: decreased resistance to bifonazole: decreased resistance to amphotericin B: decreased resistance to caffeine: decreased resistance to caspofungin: decreased resistance to cycloheximide: decreased respiratory growth: absent vegetative growth: decreased
unspecified	resistance to caffeine: decreased resistance to papulacandin B: decreased resistance to enzymatic treatment: decreased
Large-scale survey
null	haploproficient inviable starvation resistance: decreased
reduction of function	competitive fitness: increased
unspecified	resistance to Calcofluor White: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	48 total interaction(s) for 45 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 Affinity Capture-RNA: 1
Genetic Interactions	Negative Genetic: 10 Phenotypic Suppression: 2 Positive Genetic: 3 Synthetic Growth Defect: 2 Synthetic Lethality: 6 Synthetic Rescue: 23
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIII:109105 to 110670 | ORF Map | GBrowse
Last Update	Coordinates: 2006-01-12 | Sequence: 2000-02-10
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1566 109105..110670 2006-01-12 2000-02-10
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000510