Standard Name	SSH1 (see Nomenclature conflict Note)
Systematic Name	YBR283C
Feature Type	ORF, Verified
Description	Subunit of the Ssh1 translocon complex; Sec61p homolog involved in co-translational pathway of protein translocation; not essential (1, 2)
Name Description	Sec Sixty-one Homolog 1

Chromosomal Location	ChrII:770415 to 768943 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for SSH1
Molecular Function
Manually curated	protein transmembrane transporter activity (ISA) signal sequence binding (IDA)
Biological Process
Manually curated	SRP-dependent cotranslational protein targeting to membrane (IGI, IMP)
Cellular Component
Manually curated	Ssh1 translocon complex (IDA)
High-throughput	integral to membrane (ISM)

Classical genetics
null	heat sensitivity: increased Nop1p distribution: abnormal Nup49p distribution: abnormal
Large-scale survey
null	competitive fitness: decreased dessication resistance: decreased fermentative growth: decreased rate haploinsufficient heat sensitivity: increased resistance to fenpropimorph: increased resistance to fluconazole: increased resistance to ethanol: decreased resistance to methyl methanesulfonate: decreased resistance to neothyonidioside: decreased resistance to 4-chlorophenol: decreased resistance to camptothecin: decreased resistance to hydroxyurea: decreased resistance to tunicamycin: decreased resistance to cycloheximide: increased resistance to L-1,4-dithiothreitol: decreased respiratory growth: decreased respiratory growth: absent telomere length: increased toxin resistance: decreased viable
overexpression	resistance to sirolimus: increased vegetative growth: decreased vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	255 total interaction(s) for 139 unique genes/features.
Physical Interactions	Affinity Capture-MS: 6 Affinity Capture-RNA: 2 PCA: 36 Reconstituted Complex: 1
Genetic Interactions	Dosage Rescue: 2 Negative Genetic: 109 Phenotypic Enhancement: 51 Phenotypic Suppression: 29 Positive Genetic: 9 Synthetic Growth Defect: 5 Synthetic Lethality: 4 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrII:770415 to 768943 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1473 770415..768943 2011-02-03 1997-01-28
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000487