DPB3/YBR278W Summary Help

DPB3 BASIC INFORMATION

Standard Name DPB3
Systematic Name YBR278W
Feature Type ORF, Verified
Description Third-largest subunit of DNA polymerase II (DNA polymerase epsilon), required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing; mRNA abundance peaks at the G1/S boundary of the cell cycle (1, 2, 3)
Name Description DNA Polymerase B (II) subunit
GO Annotations All DPB3 GO evidence and references
    View Computational GO annotations for DPB3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All DPB3 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions DPB3 All interactions details and references
87 total interaction(s) for 49 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 19
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 5
  • Co-fractionation: 1
  • Co-purification: 4
  • Reconstituted Complex: 4
  • Two-hybrid: 5
Genetic Interactions
  • Dosage Rescue: 1
  • Phenotypic Enhancement: 21
  • Phenotypic Suppression: 7
  • Synthetic Growth Defect: 12
  • Synthetic Lethality: 4
  • Synthetic Rescue: 3
Sequence Information
ChrII:760290 to 760895 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2004-07-16 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..606 760290..760895 2004-07-16 1997-01-28
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000000482

DPB3 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for DPB3

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for DPB3]

1) Araki H, et al.  (1991) Cloning DPB3, the gene encoding the third subunit of DNA polymerase II of Saccharomyces cerevisiae. Nucleic Acids Res 19(18):4867-72
2) Li Y, et al.  (2000) Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon. J Biol Chem 275(30):23247-52
3) Iida T and Araki H  (2004) Noncompetitive counteractions of DNA polymerase epsilon and ISW2/yCHRAC for epigenetic inheritance of telomere position effect in Saccharomyces cerevisiae. Mol Cell Biol 24(1):217-27