Standard Name	RIF1 1
Systematic Name	YBR275C
Feature Type	ORF, Verified
Description	Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation (2, 3, 4)
Name Description	RAP1-Interacting Factor 1

Chromosomal Location	ChrII:757106 to 751356 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for RIF1
Molecular Function
Manually curated	telomeric DNA binding (IDA, IPI)
Biological Process
Manually curated	chromatin silencing at silent mating-type cassette (IMP) telomere capping (IMP) telomere maintenance (IMP)
Cellular Component
Manually curated	nuclear telomere cap complex (IDA)

Classical genetics
null	chromosome/plasmid maintenance: abnormal replicative lifespan: decreased silencing: increased telomere length: increased
Large-scale survey
null	competitive fitness: decreased resistance to tunicamycin: increased resistance to cycloheximide: decreased resistance to fluconazole: increased resistance to mycophenolic acid: increased resistance to methyl methanesulfonate: decreased resistance to bleomycin: decreased resistance to benzo[a]pyrene: decreased telomere length: increased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	95 total interaction(s) for 65 unique genes/features.
Physical Interactions	Affinity Capture-MS: 18 Two-hybrid: 2
Genetic Interactions	Dosage Rescue: 2 Negative Genetic: 28 Phenotypic Enhancement: 15 Phenotypic Suppression: 9 Positive Genetic: 2 Synthetic Growth Defect: 8 Synthetic Lethality: 2 Synthetic Rescue: 9
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrII:757106 to 751356 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..5751 757106..751356 2011-02-03 2011-02-03
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000479