RGD1/YBR260C Summary

RGD1 BASIC INFORMATION

Standard Name	RGD1
Systematic Name	YBR260C
Feature Type	ORF, Verified
Description	GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization (1, 2)
Name Description	Related GAP Domain 1

GO Annotations	All RGD1 GO evidence and references
	View Computational GO annotations for RGD1
Molecular Function
Manually curated	phosphatidylinositol 3-phosphate binding (IDA, IMP) phosphatidylinositol-3,5-bisphosphate binding (IDA, IMP) phosphatidylinositol-4-phosphate binding (IDA, IMP) phosphatidylinositol-5-phosphate binding (IDA, IMP) Rho GTPase activator activity (IDA)
Biological Process
Manually curated	osmosensory signaling pathway (IGI) response to acid (IMP)
Cellular Component
Manually curated	actin cortical patch (IDA) cellular bud (IDA)
High-throughput	mating projection tip (IDA)

Mutant Phenotype	All RGD1 Phenotype details and references
Classical genetics
null	resistance to tunicamycin: decreased resistance to L-1,4-dithiothreitol: decreased resistance to mercaptoethanol: normal
Large-scale survey
null	chitin deposition: normal competitive fitness: decreased resistance to Calcofluor White: normal resistance to cadmium dichloride: decreased resistance to diltiazem-HCl: decreased resistance to tunicamycine: decreased sporulation: normal viable
overexpression	vegetative growth: decreased

Interactions	RGD1 All interactions details and references
	45 total interaction(s) for 28 unique genes/features.
Physical Interactions	Affinity Capture-MS: 6 Two-hybrid: 10
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 6 Phenotypic Enhancement: 1 Phenotypic Suppression: 1 Synthetic Growth Defect: 5 Synthetic Lethality: 12 Synthetic Rescue: 3

Sequence Information

ChrII:734634 to 732634 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2004-07-16 | Sequence: 1997-01-28

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2001	734634..732634	2004-07-16	1997-01-28

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000000464

RGD1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for RGD1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for RGD1]

1)	Barthe C, et al. (1998) First characterization of the gene RGD1 in the yeast Saccharomyces cerevisiae. C R Acad Sci III 321(6):453-62
2)	Roumanie O, et al. (2000) Evidence for the genetic interaction between the actin-binding protein Vrp1 and the RhoGAP Rgd1 mediated through Rho3p and Rho4p in Saccharomyces cerevisiae. Mol Microbiol 36(6):1403-14

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