Standard Name	DUT1
Systematic Name	YBR252W
Feature Type	ORF, Verified
Description	deoxyuridine triphosphate diphosphatase (dUTPase); catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability; also has diphosphatase activity on deoxyinosine triphosphate (1, 2, 3)
Name Description	DUTp pyrophosphatase 4

Chromosomal Location	ChrII:722611 to 723054 | ORF Map | GBrowse

	View Computational GO annotations for DUT1
Molecular Function
Manually curated	dITP diphosphatase activity (IDA) dUTP diphosphatase activity (IDA, IMP)
Biological Process
Manually curated	dITP catabolic process (IDA) dUTP catabolic process (IDA, IMP) pyrimidine deoxyribonucleoside triphosphate catabolic process (IMP)
Cellular Component
High-throughput	cytoplasm (IDA) nucleus (IDA)

Pathways	de novo biosynthesis of pyrimidine deoxyribonucleotides

Classical genetics
null	auxotrophy
reduction of function	cell cycle progression through the G2/M phase transition: arrested colony size: decreased growth in exponential phase: decreased rate mutation frequency: increased
Large-scale survey
null	inviable
reduction of function	competitive fitness: decreased resistance to sirolimus: decreased resistance to hydroxyurea: decreased resistance to methyl methanesulfonate: decreased
repressible	cell cycle progression in S phase: abnormal
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	50 total interaction(s) for 47 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 Affinity Capture-RNA: 2 Reconstituted Complex: 5 Two-hybrid: 3
Genetic Interactions	Dosage Rescue: 3 Negative Genetic: 5 Phenotypic Enhancement: 1 Positive Genetic: 20 Synthetic Growth Defect: 7 Synthetic Lethality: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrII:722611 to 723054 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..444 722611..723054 2011-02-03 1997-01-28
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000456