ISW1/YBR245C Summary

ISW1 BASIC INFORMATION

Standard Name	ISW1 1
Systematic Name	YBR245C
Alias	SGN2 2
Feature Type	ORF, Verified
Description	Member of the imitation-switch (ISWI) class of ATP-dependent chromatin remodeling complexes; ATPase that forms a complex with Ioc2p and Ioc4p to regulate transcription elongation, and a complex with Ioc3p to repress transcription initiation (1, 3, 4)
Name Description	Imitation SWitch subfamily 1

GO Annotations	All ISW1 GO evidence and references
	View Computational GO annotations for ISW1
Molecular Function
Manually curated	contributes_to ATPase activity (IDA) contributes_to DNA binding (IDA) contributes_to nucleosome binding (IDA)
Biological Process
Manually curated	chromatin remodeling (IGI, IMP, IPI) nucleosome positioning (IGI, IMP) positive regulation of transcription from RNA polymerase II promoter (IMP) RNA elongation (IDA, IMP)
Cellular Component
Manually curated	ISW1 complex (IPI)

Mutant Phenotype	All ISW1 Phenotype details and references
Classical genetics
null	heat sensitivity: increased heat sensitivity: normal viable
Large-scale survey
null	resistance to tenovin-6: decreased resistance to 5-fluorouracil: decreased viable

Interactions	ISW1 All interactions details and references
	180 total interaction(s) for 103 unique genes/features.
Physical Interactions	Affinity Capture-MS: 87 Affinity Capture-RNA: 1 Affinity Capture-Western: 11 Reconstituted Complex: 1
Genetic Interactions	Phenotypic Enhancement: 26 Phenotypic Suppression: 8 Synthetic Growth Defect: 24 Synthetic Lethality: 19 Synthetic Rescue: 3

Sequence Information

ChrII:711534 to 708145 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2004-07-16 | Sequence: 1997-01-28

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..3390	711534..708145	2004-07-16	1997-01-28

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000000449

ISW1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for ISW1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for ISW1]

1)	Tsukiyama T, et al. (1999) Characterization of the imitation switch subfamily of ATP-dependent chromatin-remodeling factors in Saccharomyces cerevisiae. Genes Dev 13(6):686-97
2)	Entian KD, et al. (1999) Functional analysis of 150 deletion mutants in Saccharomyces cerevisiae by a systematic approach. Mol Gen Genet 262(4-5):683-702
3)	Morillon A, et al. (2003) Isw1 chromatin remodeling ATPase coordinates transcription elongation and termination by RNA polymerase II. Cell 115(4):425-35
4)	Mellor J and Morillon A (2004) ISWI complexes in Saccharomyces cerevisiae. Biochim Biophys Acta 1677(1-3):100-12

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