Standard Name	GPX2 1
Systematic Name	YBR244W
Alias	AMI1
Feature Type	ORF, Verified
Description	Phospholipid hydroperoxide glutathione peroxidase; protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress; induced by glucose starvation; protein abundance increases in response to DNA replication stress (1, 2, 3)
Name Description	Glutathione PeroXidase 1

Chromosomal Location	ChrII:707528 to 708016 | ORF Map | GBrowse

	View Computational GO annotations for GPX2
Molecular Function
Manually curated	glutathione peroxidase activity (IDA, IMP, ISS) phospholipid-hydroperoxide glutathione peroxidase activity (IDA, IMP)
Biological Process
Manually curated	cellular response to oxidative stress (IMP)
Cellular Component
Manually curated	cytoplasm (IDA) extrinsic to mitochondrial inner membrane (IDA) extrinsic to mitochondrial outer membrane (IDA)
High-throughput	cytoplasm (IDA) nucleus (IDA)

Pathways	glutathione-glutaredoxin redox reactions

Classical genetics
null	gamma ray resistance: decreased resistance to tert-butylhydroperoxide: decreased
Large-scale survey
null	competitive fitness: increased gamma ray resistance: decreased sporulation efficiency: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	58 total interaction(s) for 45 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 2 PCA: 7 Two-hybrid: 3
Genetic Interactions	Negative Genetic: 36 Positive Genetic: 1 Synthetic Growth Defect: 9
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrII:707528 to 708016 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..489 707528..708016 2011-02-03 1997-01-28
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000448