GPX2/YBR244W Summary Help

Standard Name GPX2 1
Systematic Name YBR244W
Alias AMI1
Feature Type ORF, Verified
Description Phospholipid hydroperoxide glutathione peroxidase; protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress; induced by glucose starvation; protein abundance increases in response to DNA replication stress (1, 2, 3)
Name Description Glutathione PeroXidase 1
Chromosomal Location
ChrII:707528 to 708016 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All GPX2 GO evidence and references
  View Computational GO annotations for GPX2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 19 genes
Resources
Pathways
Classical genetics
null
Large-scale survey
null
Resources
58 total interaction(s) for 45 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 2
  • PCA: 7
  • Two-hybrid: 3

Genetic Interactions
  • Negative Genetic: 36
  • Positive Genetic: 1
  • Synthetic Growth Defect: 9

Resources
Expression Summary
histogram
Resources
Length (a.a.) 162
Molecular Weight (Da) 18,406
Isoelectric Point (pI) 8.82
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrII:707528 to 708016 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..489 707528..708016 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000448
References cited on this page View Complete Literature Guide for GPX2
1) Inoue Y, et al.  (1999) Genetic analysis of glutathione peroxidase in oxidative stress response of Saccharomyces cerevisiae. J Biol Chem 274(38):27002-9
2) Avery AM and Avery SV  (2001) Saccharomyces cerevisiae expresses three phospholipid hydroperoxide glutathione peroxidases. J Biol Chem 276(36):33730-5
3) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76