ARC40/YBR234C Summary

ARC40 BASIC INFORMATION

Standard Name	ARC40 1
Systematic Name	YBR234C
Feature Type	ORF, Verified
Description	Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches (1, 2)
Name Description	ARp2/3 Complex subunit 1

GO Annotations	All ARC40 GO evidence and references
	View Computational GO annotations for ARC40
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	actin filament organization (IMP) actin nucleation (IDA) mitochondrion inheritance (TAS)
Cellular Component
Manually curated	Arp2/3 protein complex (IDA)

Mutant Phenotype	All ARC40 Phenotype details and references
Classical genetics
null	actin cytoskeleton morphology: abnormal growth in exponential phase: decreased rate inviable spore germination: decreased viable
Large-scale survey
conditional	heat sensitivity: increased
null	inviable
repressible	mitochondrial morphology: abnormal

Interactions	ARC40 All interactions details and references
	135 total interaction(s) for 75 unique genes/features.
Physical Interactions	Affinity Capture-MS: 48 Affinity Capture-RNA: 1 Affinity Capture-Western: 8 Co-purification: 1 PCA: 25 Reconstituted Complex: 3 Two-hybrid: 5
Genetic Interactions	Synthetic Lethality: 44

Sequence Information

ChrII:686587 to 685433 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2004-07-16 | Sequence: 1997-01-28

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1155	686587..685433	2004-07-16	1997-01-28

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000000438

ARC40 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for ARC40

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for ARC40]

1)	Winter DC, et al. (1999) Genetic dissection of the budding yeast Arp2/3 complex: a comparison of the in vivo and structural roles of individual subunits. Proc Natl Acad Sci U S A 96(13):7288-93
2)	Pan F, et al. (2004) ARPC1/Arc40 mediates the interaction of the actin-related protein 2 and 3 complex with Wiskott-Aldrich syndrome protein family activators. J Biol Chem 279(52):54629-36

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