SLX1/YBR228W Summary Help

Standard Name SLX1 1
Systematic Name YBR228W
Feature Type ORF, Verified
Description Endonuclease involved in DNA recombination and repair; subunit of a complex, with Slx4p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p (2)
Name Description Synthetic Lethal of unknown (X) function 1
Chromosomal Location
ChrII:675313 to 676227 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SLX1 GO evidence and references
  View Computational GO annotations for SLX1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Classical genetics
null
Large-scale survey
null
Resources
76 total interaction(s) for 43 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 3
  • Co-purification: 1
  • Two-hybrid: 3

Genetic Interactions
  • Negative Genetic: 40
  • Phenotypic Enhancement: 5
  • Positive Genetic: 1
  • Synthetic Growth Defect: 5
  • Synthetic Lethality: 13

Resources
Expression Summary
histogram
Resources
Length (a.a.) 304
Molecular Weight (Da) 35,856
Isoelectric Point (pI) 9.31
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrII:675313 to 676227 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..915 675313..676227 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000432
References cited on this page View Complete Literature Guide for SLX1
1) Mullen JR, et al.  (2001) Requirement for three novel protein complexes in the absence of the Sgs1 DNA helicase in Saccharomyces cerevisiae. Genetics 157(1):103-18
2) Fricke WM and Brill SJ  (2003) Slx1-Slx4 is a second structure-specific endonuclease functionally redundant with Sgs1-Top3. Genes Dev 17(14):1768-78