HPC2/YBR215W Summary Help

Standard Name HPC2 1
Systematic Name YBR215W
Feature Type ORF, Verified
Description Subunit of the HIR complex; HIR is a nucleosome assembly complex involved in regulation of histone gene transcription; mutants display synthetic defects with subunits of FACT, a complex that allows passage of RNA Pol II through nucleosomes (1, 2, 3)
Name Description Histone Periodic Control 1
Chromosomal Location
ChrII:653356 to 655317 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All HPC2 GO evidence and references
  View Computational GO annotations for HPC2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 5 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
unspecified
Resources
168 total interaction(s) for 122 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 27
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 5
  • Co-localization: 2
  • PCA: 1

Genetic Interactions
  • Dosage Lethality: 2
  • Dosage Rescue: 1
  • Negative Genetic: 91
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 2
  • Positive Genetic: 11
  • Synthetic Growth Defect: 15
  • Synthetic Lethality: 9

Resources
Expression Summary
histogram
Resources
Length (a.a.) 625
Molecular Weight (Da) 67,775
Isoelectric Point (pI) 10.04
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrII:653356 to 655317 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2007-07-09
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..13 653356..653368 2011-02-03 2007-07-09
Intron 14..97 653369..653452 2011-02-03 2007-07-09
CDS 98..1962 653453..655317 2011-02-03 2007-07-09
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000419
References cited on this page View Complete Literature Guide for HPC2
1) Xu H, et al.  (1992) Identification of a new set of cell cycle-regulatory genes that regulate S-phase transcription of histone genes in Saccharomyces cerevisiae. Mol Cell Biol 12(11):5249-59
2) Formosa T, et al.  (2002) Defects in SPT16 or POB3 (yFACT) in Saccharomyces cerevisiae cause dependence on the Hir/Hpc pathway: polymerase passage may degrade chromatin structure. Genetics 162(4):1557-71
3) Prochasson P, et al.  (2005) The HIR corepressor complex binds to nucleosomes generating a distinct protein/DNA complex resistant to remodeling by SWI/SNF. Genes Dev 19(21):2534-9