Standard Name	HPC2 1
Systematic Name	YBR215W
Feature Type	ORF, Verified
Description	Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; mutants display synthetic defects with subunits of FACT, a complex that allows passage of RNA Pol II through nucleosomes (1, 2, 3)
Name Description	Histone Periodic Control 1

Chromosomal Location	ChrII:653356 to 655317 | ORF Map | GBrowse

	View Computational GO annotations for HPC2
Molecular Function
Manually curated	contributes_to DNA binding (IDA) contributes_to nucleosome binding (IMP)
Biological Process
Manually curated	DNA replication-independent nucleosome assembly (IDA) regulation of transcription involved in G1/S phase of mitotic cell cycle (IMP) transcription elongation from RNA polymerase II promoter (IGI)
Cellular Component
Manually curated	HIR complex (IDA, IPI) nucleus (IC)

Classical genetics
null	heat sensitivity: increased replicative lifespan: increased resistance to benomyl: decreased viable
Large-scale survey
null	competitive fitness: decreased dessication resistance: decreased haploproficient heat sensitivity: increased hyperosmotic stress resistance: decreased Hta1p-GFP accumulation: increased resistance to sulfometuron methyl: decreased resistance to streptomycin: decreased resistance to amitrole: decreased resistance to quinine: decreased resistance to cycloheximide: decreased transposable element transposition: increased viable
overexpression	resistance to sirolimus: decreased vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	162 total interaction(s) for 119 unique genes/features.
Physical Interactions	Affinity Capture-MS: 26 Affinity Capture-RNA: 1 Affinity Capture-Western: 4 Co-localization: 2 PCA: 1
Genetic Interactions	Dosage Lethality: 2 Dosage Rescue: 1 Negative Genetic: 87 Phenotypic Enhancement: 1 Phenotypic Suppression: 2 Positive Genetic: 11 Synthetic Growth Defect: 15 Synthetic Lethality: 9
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrII:653356 to 655317 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 2007-07-09
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..13 653356..653368 2011-02-03 2007-07-09 Intron 14..97 653369..653452 2011-02-03 2007-07-09 CDS 98..1962 653453..655317 2011-02-03 2007-07-09
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS) Intron (14 - 97)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000419