SDS24/YBR214W Summary Help

Standard Name SDS24 1
Systematic Name YBR214W
Feature Type ORF, Verified
Description Protein involved in cell separation during budding; one of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; may play an indirect role in fluid-phase endocytosis; protein abundance increases in response to DNA replication stress; SDS24 has a paralog, SDS23, that arose from the whole genome duplication (1, 2, 3, 4, 5)
Name Description homolog of S. pombe SDS23 3
Chromosomal Location
ChrII:651415 to 652998 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SDS24 GO evidence and references
  View Computational GO annotations for SDS24
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 11 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
Resources
46 total interaction(s) for 35 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • Affinity Capture-RNA: 2
  • PCA: 4
  • Two-hybrid: 1

Genetic Interactions
  • Negative Genetic: 30
  • Phenotypic Enhancement: 1
  • Synthetic Growth Defect: 3
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 527
Molecular Weight (Da) 57,187
Isoelectric Point (pI) 9.45
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrII:651415 to 652998 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1584 651415..652998 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000418
References cited on this page View Complete Literature Guide for SDS24
1) Goldar M, et al.  (2005) Functional conservation between fission yeast moc1/sds23 and its two orthologs, budding yeast SDS23 and SDS24, and phenotypic differences in their disruptants. Biosci Biotechnol Biochem 69(7):1422-6
2) Wiederkehr A, et al.  (2001) Identification and characterization of Saccharomyces cerevisiae mutants defective in fluid-phase endocytosis. Yeast 18(8):759-73
3) Jones AL, et al.  (2000) SAC3 may link nuclear protein export to cell cycle progression. Proc Natl Acad Sci U S A 97(7):3224-9
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76