NGR1/YBR212W Summary Help

Standard Name NGR1 1, 2 (see Nomenclature conflict Note)
Systematic Name YBR212W
Alias RBP1 3
Feature Type ORF, Verified
Description RNA binding protein that negatively regulates growth rate; interacts with the 3' UTR of the mitochondrial porin (POR1) mRNA and enhances its degradation; overexpression impairs mitochondrial function; interacts with Dhh1p to mediate POR1 mRNA decay; expressed in stationary phase (3, 4, 5, 6, 7)
Name Description Negative Growth Regulatory protein
Chromosomal Location
ChrII:647886 to 649904 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All NGR1 GO evidence and references
  View Computational GO annotations for NGR1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant phenotypes All NGR1 Phenotype evidence and references
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
interactions All NGR1 Interaction evidence and references
73 total interaction(s) for 67 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 6
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 1
  • Biochemical Activity: 2
  • PCA: 1
  • Reconstituted Complex: 2
  • Two-hybrid: 4
Genetic Interactions
  • Dosage Lethality: 2
  • Dosage Rescue: 1
  • Negative Genetic: 24
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 2
  • Positive Genetic: 24
  • Synthetic Growth Defect: 1
Resources
Expression Summary
histogram
Resources
Protein Information All NGR1 Protein evidence and references
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrII:647886 to 649904 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2019 647886..649904 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000416

NOMENCLATURE CONFLICT NOTE

NameRelevanceDescription
FPR1Nomenclature conflictRBP1 has been used to refer to both NGR1/YBR212W, which encodes an RNA- and single-stranded DNA-binding protein, and FPR1/YNL135C, which encodes a peptidyl-prolyl cis-trans isomerase.
SGN1Nomenclature conflictRBP1 has been used to refer to both NGR1/YBR212W, which encodes an RNA- and single-stranded DNA-binding protein, and SGN1/YIR001C, which encodes a poly(A)-binding protein.
References cited on this page View Complete Literature Guide for NGR1
1) Li AM, et al.  (2003) Scp160p associates with specific mRNAs in yeast. Nucleic Acids Res 31(7):1830-7
2) Gardner JM, et al.  (2005) Identification of genes affecting glucose catabolism in nitrogen-limited fermentation. FEMS Yeast Res 5(9):791-800
3) Lee FJ and Moss J  (1993) An RNA-binding protein gene (RBP1) of Saccharomyces cerevisiae encodes a putative glucose-repressible protein containing two RNA recognition motifs. J Biol Chem 268(20):15080-7
4) Akada R, et al.  (1997) Screening and identification of yeast sequences that cause growth inhibition when overexpressed. Mol Gen Genet 254(3):267-74
5) Buu LM, et al.  (2004) The yeast RNA-binding protein Rbp1p modifies the stability of mitochondrial porin mRNA. J Biol Chem 279(1):453-62
6) Martinez MJ, et al.  (2004) Genomic analysis of stationary-phase and exit in Saccharomyces cerevisiae: gene expression and identification of novel essential genes. Mol Biol Cell 15(12):5295-305
7) Chang LC and Lee FJ  (2012) The RNA helicase Dhh1p cooperates with Rbp1p to promote porin mRNA decay via its non-conserved C-terminal domain. Nucleic Acids Res 40(3):1331-44