MBA1/YBR185C Summary Help

Standard Name MBA1
Systematic Name YBR185C
Feature Type ORF, Verified
Description Membrane-associated mitochondrial ribosome receptor; forms a complex with Mdm38p that may facilitate recruitment of mRNA-specific translational activators to ribosomes; possible role in protein export from the matrix to inner membrane (1, 2, 3, 4 and see Summary Paragraph)
Name Description Multi-copy Bypass of AFG3 1
Chromosomal Location
ChrII:599959 to 599123 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All MBA1 GO evidence and references
  View Computational GO annotations for MBA1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant phenotypes All MBA1 Phenotype evidence and references
Classical genetics
null
Large-scale survey
null
Resources
interactions All MBA1 Interaction evidence and references
91 total interaction(s) for 86 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 7
  • Affinity Capture-Western: 1
Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 2
  • Negative Genetic: 68
  • Positive Genetic: 8
  • Synthetic Growth Defect: 4
Resources
Expression Summary
histogram
Resources
Protein Information All MBA1 Protein evidence and references
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrII:599959 to 599123 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..837 599959..599123 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000389
SUMMARY PARAGRAPH for MBA1

MBA1 encodes a protein involved in the insertion of proteins into the mitochondrial inner membrane (2). Mba1p is proposed to act as a receptor for proteins destined for export from the mitochondrial matrix to the inner membrane, transferring them to other components of the mitochondrial export process (2). Consistent with this proposed function, it is exposed on the matrix face of the mitochondrial inner membrane, where it interacts transiently with several different mitochondrially-encoded nascent peptides and also with nuclearly-encoded proteins (2). The phenotype of the mba1 null mutation is a partial respiratory growth defect (1). Overproduction of Mba1p suppresses the respiratory defect caused by afg3 or yta12 null mutations (5).

Last updated: 2002-06-12

References cited on this page View Complete Literature Guide for MBA1
1) Rep M and Grivell LA  (1996) MBA1 encodes a mitochondrial membrane-associated protein required for biogenesis of the respiratory chain. FEBS Lett 388(2-3):185-8
2) Preuss M, et al.  (2001) Mba1, a novel component of the mitochondrial protein export machinery of the yeast Saccharomyces cerevisiae. J Cell Biol 153(5):1085-96
3) Ott M, et al.  (2006) Mba1, a membrane-associated ribosome receptor in mitochondria. EMBO J 25(8):1603-10
4) Bauerschmitt H, et al.  (2010) Ribosome-binding proteins Mdm38 and Mba1 display overlapping functions for regulation of mitochondrial translation. Mol Biol Cell 21(12):1937-44
5) Rep M, et al.  (1996) Three genes for mitochondrial proteins suppress null-mutations in both Afg3 and Rca1 when over-expressed. Curr Genet 30(3):206-11