SWD3/YBR175W Summary Help

SWD3 BASIC INFORMATION

Standard Name SWD3 1
Systematic Name YBR175W
Alias CPS30 2 , SAF35 3
Feature Type ORF, Verified
Description Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5 (1, 2, 3, 4, 5, 6)
Name Description Set1c, WD40 repeat protein
GO Annotations All SWD3 GO evidence and references
    View Computational GO annotations for SWD3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All SWD3 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions SWD3 All interactions details and references
358 total interaction(s) for 203 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 52
  • Affinity Capture-Western: 2
  • Biochemical Activity: 2
  • Co-purification: 1
  • Protein-RNA: 1
  • Two-hybrid: 1
Genetic Interactions
  • Phenotypic Enhancement: 173
  • Phenotypic Suppression: 41
  • Synthetic Growth Defect: 34
  • Synthetic Lethality: 49
  • Synthetic Rescue: 2
Sequence Information
ChrII:582403 to 583350 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2004-07-16 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..948 582403..583350 2004-07-16 1997-01-28
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000000379

SWD3 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
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  • Comparison Resources
  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for SWD3

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SWD3]

1) Roguev A, et al.  (2001) The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4. EMBO J 20(24):7137-48
2) Miller T, et al.  (2001) COMPASS: a complex of proteins associated with a trithorax-related SET domain protein. Proc Natl Acad Sci U S A 98(23):12902-7
3) Nagy PL, et al.  (2002) A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3. Proc Natl Acad Sci U S A 99(1):90-4
4) Krogan NJ, et al.  (2002) COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression. J Biol Chem 277(13):10753-5
5) Dover J, et al.  (2002) Methylation of histone H3 by COMPASS requires ubiquitination of histone H2B by Rad6. J Biol Chem 277(32):28368-71
6) Cheng H, et al.  (2004) The essential WD repeat protein Swd2 has dual functions in RNA polymerase II transcription termination and lysine 4 methylation of histone H3. Mol Cell Biol 24(7):2932-43