Standard Name	UMP1 1
Systematic Name	YBR173C
Alias	RNS2 2
Feature Type	ORF, Verified
Description	Short-lived chaperone required for correct maturation of the 20S proteasome; may inhibit premature dimerization of proteasome half-mers; degraded by proteasome upon completion of its assembly (1, 3, 4, 5)
Name Description	Ubiquitin-Mediated Proteolysis 1

Chromosomal Location	ChrII:582172 to 581726 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for UMP1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	proteasome assembly (IGI, IMP) response to DNA damage stimulus (IDA) ubiquitin-dependent protein catabolic process (IMP)
Cellular Component
Manually curated	cytoplasm (IDA) nucleus (IDA)

Classical genetics
null	heat sensitivity: increased mutation frequency: increased replicative lifespan: decreased resistance to camptothecin: increased resistance to methyl methanesulfonate: increased resistance to 4-nitroquinoline N-oxide: increased resistance to canavanine: decreased resistance to staurosporine: decreased resistance to tunicamycin: decreased vegetative growth: decreased rate vegetative growth: decreased
overexpression	resistance to hydrogen peroxide: increased resistance to menadione: increased resistance to 4-hydroxynon-2-enal: increased survival rate in stationary phase: increased
Large-scale survey
null	glutathione excretion: increased competitive fitness: decreased dessication resistance: decreased haploinsufficient Rpn4p11-229-His3 accumulation: increased Protein A-nonstop protein accumulation: increased resistance to caffeine: decreased resistance to benomyl: decreased resistance to tirapazamine: increased resistance to benzo[a]pyrene: increased resistance to sulfometuron methyl: decreased resistance to dimethyl sulfoxide: decreased resistance to sirolimus: decreased resistance to hygromycin B: decreased resistance to alverine citrate: decreased resistance to dyclonine: decreased sporulation: decreased transposable element transposition: decreased utilization of iron source: decreased vacuolar morphology: abnormal vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	132 total interaction(s) for 101 unique genes/features.
Physical Interactions	Affinity Capture-MS: 31 Affinity Capture-RNA: 2 Affinity Capture-Western: 8 Biochemical Activity: 1 Co-fractionation: 2 Co-localization: 3 Co-purification: 1 Two-hybrid: 3
Genetic Interactions	Dosage Growth Defect: 3 Dosage Rescue: 1 Negative Genetic: 42 Phenotypic Enhancement: 3 Phenotypic Suppression: 6 Positive Genetic: 6 Synthetic Growth Defect: 8 Synthetic Lethality: 6 Synthetic Rescue: 6
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrII:582172 to 581726 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..447 582172..581726 2011-02-03 1997-01-28
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000377