Standard Name	TYR1
Systematic Name	YBR166C
Feature Type	ORF, Verified
Description	Prephenate dehydrogenase involved in tyrosine biosynthesis, expression is dependent on phenylalanine levels (1)
Name Description	TYRosine requiring

Chromosomal Location	ChrII:571200 to 569842 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 97 cM

	View Computational GO annotations for TYR1
Molecular Function
Manually curated	prephenate dehydrogenase activity (ISS)
Biological Process
Manually curated	tyrosine metabolic process (NAS)
Cellular Component
High-throughput	cytoplasm (IDA)

Pathways	pathways of chorismate superpathway of phenylalanine, tyrosine and tryptophan biosynthesis tyrosine biosynthesis

Classical genetics
null	resistance to 2-phenylethanol: decreased
Large-scale survey
null	alkaline pH resistance: decreased anaerobic growth: decreased chitin deposition: normal competitive fitness: decreased haploproficient resistance to cycloheximide: decreased resistance to ethanol: decreased resistance to propan-1-ol: decreased resistance to (S)-lactic acid: decreased resistance to acetic acid: decreased resistance to hydrogen chloride: decreased starvation resistance: decreased utilization of nitrogen source: absent vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	20 total interaction(s) for 18 unique genes/features.
Physical Interactions	Affinity Capture-MS: 5 Affinity Capture-RNA: 1 Two-hybrid: 2
Genetic Interactions	Negative Genetic: 4 Positive Genetic: 4 Synthetic Growth Defect: 1 Synthetic Lethality: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrII:571200 to 569842 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 97 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1359 571200..569842 2011-02-03 1997-01-28
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000370