AMN1/YBR158W Summary Help

Standard Name AMN1 1
Systematic Name YBR158W
Alias ICS4 2 , CST13 3
Feature Type ORF, Verified
Description Protein required for daughter cell separation; multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN) (1, 3)
Name Description Antagonist of Mitotic exit Network 1
Chromosomal Location
ChrII:556549 to 558198 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All AMN1 GO evidence and references
  View Computational GO annotations for AMN1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 19 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
55 total interaction(s) for 41 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 7
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 3
  • Co-purification: 1
  • Reconstituted Complex: 1
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Lethality: 16
  • Dosage Rescue: 1
  • Negative Genetic: 14
  • Phenotypic Suppression: 2
  • Synthetic Lethality: 1
  • Synthetic Rescue: 6

Resources
Expression Summary
histogram
Resources
Length (a.a.) 549
Molecular Weight (Da) 62,686
Isoelectric Point (pI) 9.67
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrII:556549 to 558198 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1650 556549..558198 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000362
References cited on this page View Complete Literature Guide for AMN1
1) Wang Y, et al.  (2003) Exit from exit: resetting the cell cycle through Amn1 inhibition of G protein signaling. Cell 112(5):697-709
2) Entian KD, et al.  (1999) Functional analysis of 150 deletion mutants in Saccharomyces cerevisiae by a systematic approach. Mol Gen Genet 262(4-5):683-702
3) Ouspenski II, et al.  (1999) New yeast genes important for chromosome integrity and segregation identified by dosage effects on genome stability. Nucleic Acids Res 27(15):3001-8