MAK5/YBR142W Summary Help

MAK5 BASIC INFORMATION

Standard Name MAK5
Systematic Name YBR142W
Feature Type ORF, Verified
Description Essential nucleolar protein, putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus; involved in biogenesis of large (60S) ribosomal subunits (1, 2)
Name Description MAintenance of Killer
GO Annotations All MAK5 GO evidence and references
    View Computational GO annotations for MAK5
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All MAK5 Phenotype details and references
Classical genetics
dominant negative
Large-scale survey
conditional
null
overexpression
Interactions MAK5 All interactions details and references
111 total interaction(s) for 72 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 92
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 6
  • Biochemical Activity: 2
Genetic Interactions
  • Phenotypic Enhancement: 3
  • Phenotypic Suppression: 6
  • Synthetic Lethality: 1
Sequence Information
ChrII:528311 to 530632 | ORF Map | GBrowse
Gbrowse
Genetic position: 80 cM
Last Update Coordinates: 2004-07-16 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2322 528311..530632 2004-07-16 1997-01-28
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000000346

MAK5 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Localization Resources
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  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for MAK5

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for MAK5]

1) Wickner RB and Leibowitz MJ  (1976) Chromosomal genes essential for replication of a double-stranded RNA plasmid of Saccharomyces cerevisiae: the killer character of yeast. J Mol Biol 105(3):427-43
2) Zagulski M, et al.  (2003) Mak5p, which is required for the maintenance of the M1 dsRNA virus, is encoded by the yeast ORF YBR142w and is involved in the biogenesis of the 60S subunit of the ribosome. Mol Genet Genomics 270(3):216-24