HSL7/YBR133C Summary Help

HSL7 BASIC INFORMATION

Standard Name HSL7
Systematic Name YBR133C
Feature Type ORF, Verified
Description Protein arginine N-methyltransferase that exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p (1, 2, 3, 4, 5, 6)
Name Description Histone Synthetic Lethal 7
GO Annotations All HSL7 GO evidence and references
    View Computational GO annotations for HSL7
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulatory Role
Regulatory modules predicted: cellcycle ( 281 )
Mutant Phenotype All HSL7 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions HSL7 All interactions details and references
47 total interaction(s) for 25 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-Western: 12
  • Biochemical Activity: 4
  • Co-localization: 1
  • Reconstituted Complex: 3
  • Two-hybrid: 10
Genetic Interactions
  • Dosage Rescue: 2
  • Phenotypic Suppression: 2
  • Synthetic Growth Defect: 2
  • Synthetic Haploinsufficiency: 1
  • Synthetic Lethality: 5
  • Synthetic Rescue: 2
Sequence Information
ChrII:504281 to 501798 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2004-07-16 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2484 504281..501798 2004-07-16 1997-01-28
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000000337

HSL7 RESOURCES

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Expression Summary histogram

ADDITIONAL INFORMATION for HSL7

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for HSL7]

1) McMillan JN, et al.  (1999) The morphogenesis checkpoint in Saccharomyces cerevisiae: cell cycle control of Swe1p degradation by Hsl1p and Hsl7p. Mol Cell Biol 19(10):6929-39
2) Shulewitz MJ, et al.  (1999) Hsl7 localizes to a septin ring and serves as an adapter in a regulatory pathway that relieves tyrosine phosphorylation of Cdc28 protein kinase in Saccharomyces cerevisiae. Mol Cell Biol 19(10):7123-37
3) Longtine MS, et al.  (2000) Septin-dependent assembly of a cell cycle-regulatory module in Saccharomyces cerevisiae. Mol Cell Biol 20(11):4049-61
4) Lee JH, et al.  (2000) Hsl7p, the yeast homologue of human JBP1, is a protein methyltransferase. Biochem Biophys Res Commun 274(1):105-11
5) Cid VJ, et al.  (2001) Dynamic localization of the Swe1 regulator Hsl7 during the Saccharomyces cerevisiae cell cycle. Mol Biol Cell 12(6):1645-69
6) Sakchaisri K, et al.  (2004) Coupling morphogenesis to mitotic entry. Proc Natl Acad Sci U S A 101(12):4124-9
7) Ma XJ, et al.  (1996) A search for proteins that interact genetically with histone H3 and H4 amino termini uncovers novel regulators of the Swe1 kinase in Saccharomyces cerevisiae. Genes Dev 10(11):1327-40