AGP2/YBR132C Summary Help

Standard Name AGP2 1
Systematic Name YBR132C
Feature Type ORF, Verified
Description Plasma membrane regulator of polyamine and carnitine transport; has similarity to transporters but lacks transport activity; may act as a sensor that transduces environmental signals; has a positive or negative regulatory effect on transcription of many transporter genes (1, 2, 3, 4, 5)
Name Description high-Affinity Glutamine Permease 1
Chromosomal Location
ChrII:501442 to 499652 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All AGP2 GO evidence and references
  View Computational GO annotations for AGP2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 81 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
24 total interaction(s) for 21 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • PCA: 3
  • Two-hybrid: 1

Genetic Interactions
  • Negative Genetic: 16

Resources
Expression Summary
histogram
Resources
Length (a.a.) 596
Molecular Weight (Da) 67,261
Isoelectric Point (pI) 7.16
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrII:501442 to 499652 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1791 501442..499652 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB
Primary SGDIDS000000336
References cited on this page View Complete Literature Guide for AGP2
1) Schreve JL and Garrett JM  (2004) Yeast Agp2p and Agp3p function as amino acid permeases in poor nutrient conditions. Biochem Biophys Res Commun 313(3):745-51
2) van Roermund CW, et al.  (1999) Molecular characterization of carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria in Saccharomyces cerevisiae and identification of a plasma membrane carnitine transporter, Agp2p. EMBO J 18(21):5843-52
3) Lee J, et al.  (2002) Carnitine uptake by AGP2 in yeast Saccharomyces cerevisiae is dependent on Hog1 MAP kinase pathway. Mol Cells 13(3):407-12
4) Aouida M, et al.  (2005) AGP2 encodes the major permease for high affinity polyamine import in Saccharomyces cerevisiae. J Biol Chem 280(25):24267-76
5) Aouida M, et al.  (2013) Agp2, a member of the yeast amino Acid permease family, positively regulates polyamine transport at the transcriptional level. PLoS One 8(6):e65717