Standard Name	TEF2
Systematic Name	YBR118W
Feature Type	ORF, Verified
Description	Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus; TEF2 has a paralog, TEF1, that arose from the whole genome duplication (1, 2, 3) Also known as: EF-1 alpha
Name Description	Translation Elongation Factor 1
Gene Product Alias	eEF1A 4

Chromosomal Location	ChrII:477671 to 479047 | ORF Map | GBrowse
	Genetic position: 61 cM

	View Computational GO annotations for TEF2
Molecular Function
Manually curated	GDP binding (IDA) GTP binding (IDA) translation elongation factor activity (IMP)
Biological Process
Manually curated	translational elongation (IMP) tRNA export from nucleus (IGI, IMP)
Cellular Component
Manually curated	cytoplasm (IDA) eukaryotic translation elongation factor 1 complex (ISS)

Classical genetics
null	resistance to sirolimus: decreased
overexpression	actin cytoskeleton morphology: abnormal cell size: increased vegetative growth: decreased rate
Large-scale survey
null	competitive fitness: decreased viable
overexpression	cell cycle progression: abnormal
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	213 total interaction(s) for 174 unique genes/features.
Physical Interactions	Affinity Capture-MS: 73 Affinity Capture-RNA: 4 Affinity Capture-Western: 10 Biochemical Activity: 12 Co-crystal Structure: 2 Co-fractionation: 4 PCA: 1 Reconstituted Complex: 5 Two-hybrid: 2
Genetic Interactions	Dosage Growth Defect: 1 Dosage Lethality: 2 Dosage Rescue: 7 Negative Genetic: 54 Phenotypic Enhancement: 1 Phenotypic Suppression: 5 Positive Genetic: 22 Synthetic Growth Defect: 5 Synthetic Lethality: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | InterologFinder | YeastRC Mass Spec

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrII:477671 to 479047 | ORF Map | GBrowse
	Genetic position: 61 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1377 477671..479047 2011-02-03 1997-01-28
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000322