EXO84/YBR102C Summary

EXO84 BASIC INFORMATION

Standard Name	EXO84
Systematic Name	YBR102C
Alias	USA3 1
Feature Type	ORF, Verified
Description	Essential protein with dual roles in spliceosome assembly and exocytosis; the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p) mediates polarized targeting of secretory vesicles to active sites of exocytosis (1, 2, 3)
Name Description	EXOcyst

GO Annotations	All EXO84 GO evidence and references
	View Computational GO annotations for EXO84
Molecular Function
Manually curated	protein binding (IPI)
Biological Process
Manually curated	exocytosis (IGI, IMP, IPI) spliceosome assembly (IGI, IMP, IPI)
Cellular Component
Manually curated	cellular bud neck (IDA) cellular bud tip (IDA) exocyst (IPI) incipient cellular bud site (IDA)
High-throughput	mating projection tip (IDA)

Mutant Phenotype	All EXO84 Phenotype details and references
Classical genetics
overexpression	actin cytoskeleton morphology: abnormal
Large-scale survey
null	inviable resistance to 2-phenyl-3-nitroso-imidazo[1,2-a]pyridine: decreased
overexpression	vegetative growth: decreased

Interactions	EXO84 All interactions details and references
	77 total interaction(s) for 35 unique genes/features.
Physical Interactions	Affinity Capture-MS: 27 Affinity Capture-RNA: 1 Affinity Capture-Western: 9 Biochemical Activity: 3 Co-purification: 1 PCA: 3 Reconstituted Complex: 2 Two-hybrid: 12
Genetic Interactions	Dosage Rescue: 9 Synthetic Lethality: 10

Sequence Information

ChrII:447317 to 445056 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2004-07-16 | Sequence: 1997-01-28

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2262	447317..445056	2004-07-16	1997-01-28

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000000306

EXO84 RESOURCES

Click on map for expanded view

SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for EXO84

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for EXO84]

1)	Awasthi S, et al. (2001) New roles for the Snp1 and Exo84 proteins in yeast pre-mRNA splicing. J Biol Chem 276(33):31004-15
2)	Guo W, et al. (1999) Exo84p is an exocyst protein essential for secretion. J Biol Chem 274(33):23558-64
3)	Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64

SGD^tm pages Database Copyright © 1997-2010 The Board of Trustees of Leland Stanford Junior University. Permission to use the information contained in this database was given by the researchers/institutes who contributed or published the information. Users of the database are solely responsible for compliance with any copyright restrictions, including those applying to the author abstracts. Documents from this server are provided "AS-IS" without any warranty, expressed or implied. The SGD project at Stanford University is supported by a Genome Research Resource Grant from the US National Human Genome Research Institute, part of the US National Institutes of Health.