MMS4/YBR098W Summary Help

MMS4 BASIC INFORMATION

Standard Name MMS4 1
Systematic Name YBR098W
Alias SLX2 , YBR100W
Feature Type ORF, Verified
Description Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination (1, 2, 3, 4, 5)
Name Description Methyl MethaneSulfonate sensitivity 1
GO Annotations All MMS4 GO evidence and references
    View Computational GO annotations for MMS4
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All MMS4 Phenotype details and references
Classical genetics
null
reduction of function
Large-scale survey
null
Interactions MMS4 All interactions details and references
117 total interaction(s) for 67 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 2
  • Biochemical Activity: 2
  • Co-purification: 1
  • Reconstituted Complex: 2
  • Two-hybrid: 3
Genetic Interactions
  • Phenotypic Enhancement: 43
  • Synthetic Growth Defect: 17
  • Synthetic Lethality: 42
  • Synthetic Rescue: 2
Sequence Information
ChrII:441509 to 443584 | ORF Map | GBrowse
This feature contains embedded feature(s): YBR100W | YBR099C
Gbrowse
Last Update Coordinates: 2004-07-16 | Sequence: 2003-01-03
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2076 441509..443584 2004-07-16 2003-01-03
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000000302

MMS4 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for MMS4

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for MMS4]

1) Xiao W, et al.  (1998) Mms4, a putative transcriptional (co)activator, protects Saccharomyces cerevisiae cells from endogenous and environmental DNA damage. Mol Gen Genet 257(6):614-23
2) Kaliraman V, et al.  (2001) Functional overlap between Sgs1-Top3 and the Mms4-Mus81 endonuclease. Genes Dev 15(20):2730-40
3) Bastin-Shanower SA, et al.  (2003) The mechanism of Mus81-Mms4 cleavage site selection distinguishes it from the homologous endonuclease Rad1-Rad10. Mol Cell Biol 23(10):3487-96
4) Oh SD, et al.  (2008) RecQ helicase, Sgs1, and XPF family endonuclease, Mus81-Mms4, resolve aberrant joint molecules during meiotic recombination. Mol Cell 31(3):324-36
5) Jessop L and Lichten M  (2008) Mus81/Mms4 endonuclease and Sgs1 helicase collaborate to ensure proper recombination intermediate metabolism during meiosis. Mol Cell 31(3):313-23