Standard Name	RXT2 1, 2
Systematic Name	YBR095C
Alias	RAF60 3
Feature Type	ORF, Verified
Description	Subunit of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth (2, 4)

Chromosomal Location	ChrII:435698 to 434406 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for RXT2
Molecular Function
Manually curated	contributes_to histone deacetylase activity (IMP)
Biological Process
Manually curated	conjugation with cellular fusion (IMP) invasive growth in response to glucose limitation (IMP) negative regulation of chromatin silencing at rDNA (IMP) negative regulation of chromatin silencing at silent mating-type cassette (IMP) negative regulation of chromatin silencing at telomere (IMP) negative regulation of transcription from RNA polymerase II promoter (IMP)
Cellular Component
Manually curated	Rpd3L complex (IDA)
High-throughput	nucleus (IDA) Rpd3L complex (IDA) Rpd3L-Expanded complex (IDA)

Classical genetics
null	chronological lifespan: decreased resistance to cycloheximide: decreased
Large-scale survey
null	N-acetyl ornithine accumulation: increased inositol excretion: increased competitive fitness: decreased endocytosis: decreased haploinsufficient heat sensitivity: increased resistance to cycloheximide: decreased resistance to sulfanilamide: decreased resistance to ethanol: decreased resistance to sodium arsenite: decreased resistance to sirolimus: increased resistance to wortmannin: decreased vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	552 total interaction(s) for 303 unique genes/features.
Physical Interactions	Affinity Capture-MS: 64 Affinity Capture-RNA: 1 Affinity Capture-Western: 10 Two-hybrid: 6
Genetic Interactions	Negative Genetic: 342 Phenotypic Enhancement: 14 Phenotypic Suppression: 13 Positive Genetic: 70 Synthetic Growth Defect: 11 Synthetic Lethality: 11 Synthetic Rescue: 10
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrII:435698 to 434406 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 2003-09-22
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1293 435698..434406 2011-02-03 2003-09-22
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000299