RXT2/YBR095C Summary Help

Standard Name RXT2 1, 2
Systematic Name YBR095C
Alias RAF60 3
Feature Type ORF, Verified
Description Component of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth; relocalizes to the cytosol in response to hypoxia (2, 4, 5)
Chromosomal Location
ChrII:435698 to 434406 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All RXT2 GO evidence and references
  View Computational GO annotations for RXT2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 3 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
553 total interaction(s) for 303 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 64
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 10
  • Two-hybrid: 6

Genetic Interactions
  • Negative Genetic: 343
  • Phenotypic Enhancement: 14
  • Phenotypic Suppression: 13
  • Positive Genetic: 70
  • Synthetic Growth Defect: 11
  • Synthetic Lethality: 11
  • Synthetic Rescue: 10

Resources
Expression Summary
histogram
Resources
Length (a.a.) 430
Molecular Weight (Da) 48,629
Isoelectric Point (pI) 4.65
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrII:435698 to 434406 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2003-09-22
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1293 435698..434406 2011-02-03 2003-09-22
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000299
References cited on this page View Complete Literature Guide for RXT2
1) Schaft, D, et al.  (2002) personal communication
2) Carrozza MJ, et al.  (2005) Stable incorporation of sequence specific repressors Ash1 and Ume6 into the Rpd3L complex. Biochim Biophys Acta 1731(2):77-87; discussion 75-6
3) Colina AR and Young D  (2005) Raf60, a novel component of the Rpd3 histone deacetylase complex required for Rpd3 activity in Saccharomyces cerevisiae. J Biol Chem 280(52):42552-6
4) Entian KD, et al.  (1999) Functional analysis of 150 deletion mutants in Saccharomyces cerevisiae by a systematic approach. Mol Gen Genet 262(4-5):683-702
5) Ghosh Dastidar R, et al.  (2012) The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation. Cell Biosci 2(1):30