TEC1/YBR083W Summary Help

Standard Name TEC1 1
Systematic Name YBR083W
Alias ROC1 2
Feature Type ORF, Verified
Description Transcription factor targeting filamentation genes and Ty1 expression; Ste12p activation of most filamentation gene promoters depends on Tec1p and Tec1p transcriptional activity is dependent on its association with Ste12p; binds to TCS elements upstream of filamentation genes, which are regulated by Tec1p/Ste12p/Dig1p complex; competes with Dig2p for binding to Ste12p/Dig1p; positive regulator of chronological life span; TEA/ATTS DNA-binding domain family member (1, 3, 4, 5, 6)
Name Description Transposon Enhancement Control 1
Chromosomal Location
ChrII:409169 to 410629 | ORF Map | GBrowse
Gene Ontology Annotations All TEC1 GO evidence and references
  View Computational GO annotations for TEC1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Targets 165 genes
Regulators 8 genes
Classical genetics
Large-scale survey
132 total interaction(s) for 76 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 11
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 18
  • Biochemical Activity: 2
  • Protein-RNA: 1
  • Reconstituted Complex: 12
  • Two-hybrid: 2

Genetic Interactions
  • Dosage Rescue: 7
  • Negative Genetic: 40
  • Phenotypic Enhancement: 6
  • Phenotypic Suppression: 13
  • Positive Genetic: 14
  • Synthetic Rescue: 3

Expression Summary
Length (a.a.) 486
Molecular Weight (Da) 55,157
Isoelectric Point (pI) 7.71
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrII:409169 to 410629 | ORF Map | GBrowse
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..1461 409169..410629 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000287
References cited on this page View Complete Literature Guide for TEC1
1) Laloux I, et al.  (1990) TEC1, a gene involved in the activation of Ty1 and Ty1-mediated gene expression in Saccharomyces cerevisiae: cloning and molecular analysis. Mol Cell Biol 10(7):3541-50
2) Dubois E, et al.  (1982) Expression of the ROAM mutations in Saccharomyces cerevisiae: involvement of trans-acting regulatory elements and relation with the Ty1 transcription. EMBO J 1(9):1133-9
3) Kohler T, et al.  (2002) Dual role of the Saccharomyces cerevisiae TEA/ATTS family transcription factor Tec1p in regulation of gene expression and cellular development. Eukaryot Cell 1(5):673-86
4) Zeitlinger J, et al.  (2003) Program-specific distribution of a transcription factor dependent on partner transcription factor and MAPK signaling. Cell 113(3):395-404
5) Chou S, et al.  (2006) Regulation of mating and filamentation genes by two distinct Ste12 complexes in Saccharomyces cerevisiae. Mol Cell Biol 26(13):4794-805
6) Bruckner S, et al.  (2011) The TEA transcription factor Tec1 links TOR and MAPK pathways to coordinate yeast development. Genetics 189(2):479-94
7) Zhu C, et al.  (2009) High-resolution DNA-binding specificity analysis of yeast transcription factors. Genome Res 19(4):556-66
8) Madhani HD and Fink GR  (1997) Combinatorial control required for the specificity of yeast MAPK signaling. Science 275(5304):1314-7
9) Harbison CT, et al.  (2004) Transcriptional regulatory code of a eukaryotic genome. Nature 431(7004):99-104
10) Badis G, et al.  (2008) A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Mol Cell 32(6):878-87