SEC18/YBR080C Summary Help

SEC18 BASIC INFORMATION

Standard Name SEC18 1, 2
Systematic Name YBR080C
Alias ANU4
Feature Type ORF, Verified
Description ATPase required for the release of Sec17p during the 'priming' step in homotypic vacuole fusion and for ER to Golgi transport; homolog of the mammalian NSF (3, 4, 5)
Name Description SECretory 6
GO Annotations All SEC18 GO evidence and references
    View Computational GO annotations for SEC18
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant Phenotype All SEC18 Phenotype details and references
Classical genetics
conditional
null
Large-scale survey
null
overexpression
repressible
Interactions SEC18 All interactions details and references
83 total interaction(s) for 68 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 9
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 9
  • Co-fractionation: 3
  • PCA: 1
  • Reconstituted Complex: 4
  • Two-hybrid: 8
Genetic Interactions
  • Dosage Lethality: 2
  • Dosage Rescue: 3
  • Phenotypic Enhancement: 16
  • Phenotypic Suppression: 5
  • Synthetic Lethality: 22
Sequence Information
ChrII:400884 to 398608 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: 48 cM
Last Update Coordinates: 2004-07-16 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2277 400884..398608 2004-07-16 1997-01-28
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000000284

SEC18 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Literature
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  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
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  • Comparison Resources
  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for SEC18

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SEC18]

1) Novick P, et al.  (1980) Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway. Cell 21(1):205-15
2) Fields, C. and Schekman, R.  (1985) Personal Communication, Mortimer Map Edition 9
3) Newman AP and Ferro-Novick S  (1990) Defining components required for transport from the ER to the Golgi complex in yeast. Bioessays 12(10):485-91
4) Mayer A, et al.  (1996) Sec18p (NSF)-driven release of Sec17p (alpha-SNAP) can precede docking and fusion of yeast vacuoles. Cell 85(1):83-94
5) Kato M and Wickner W  (2003) Vam10p defines a Sec18p-independent step of priming that allows yeast vacuole tethering. Proc Natl Acad Sci U S A 100(11):6398-403
6) Novick P and Schekman R  (1979) Secretion and cell-surface growth are blocked in a temperature-sensitive mutant of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 76(4):1858-62