Standard Name	RPG1 1
Systematic Name	YBR079C
Alias	TIF32 2
Feature Type	ORF, Verified
Description	eIF3a subunit of the core complex of translation initiation factor 3 (eIF3), essential for translation; part of a Prt1p-Rpg1p-Nip1p subcomplex that stimulates binding of mRNA and tRNA(i)Met to ribosomes; involved in translation reinitiation (3, 4, 5, 6)

Chromosomal Location	ChrII:398277 to 395383 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for RPG1
Molecular Function
Manually curated	translation initiation factor activity (IDA)
Biological Process
Manually curated	translation reinitiation (IMP) translational initiation (IDA)
Cellular Component
Manually curated	cytoplasmic stress granule (IDA) eukaryotic translation initiation factor 3 complex (IDA, IPI) incipient cellular bud site (IDA)
High-throughput	cytoplasm (IDA)

Classical genetics
conditional	cell cycle progression in G1 phase: arrested heat sensitivity: increased mating efficiency: decreased resistance to sulfometuron: decreased resistance to paromomycin: decreased vegetative growth: decreased rate
null	dessication resistance: increased inviable
Large-scale survey
conditional	chromosome/plasmid maintenance: abnormal heat sensitivity: increased
null	inviable
overexpression	cell cycle progression: abnormal vegetative growth: decreased rate vegetative growth: decreased
reduction of function	competitive fitness: increased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	247 total interaction(s) for 113 unique genes/features.
Physical Interactions	Affinity Capture-MS: 126 Affinity Capture-RNA: 2 Affinity Capture-Western: 50 Biochemical Activity: 2 Co-crystal Structure: 1 Co-fractionation: 8 Co-purification: 6 Reconstituted Complex: 10 Two-hybrid: 12
Genetic Interactions	Dosage Growth Defect: 1 Dosage Lethality: 2 Dosage Rescue: 4 Negative Genetic: 16 Phenotypic Enhancement: 1 Positive Genetic: 2 Synthetic Growth Defect: 3 Synthetic Lethality: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrII:398277 to 395383 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2895 398277..395383 2011-02-03 1997-01-28
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000283